ArticleThe American journal of tropical medicine and hygiene2014
Chromosomal rearrangement features of Yersinia pestis strains from natural plague foci in China.
Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- A field-deployable high-resolution SNP genotyping platform for rapid surveillance ofVirulence · 2026Article
- Systematic analysis of spontaneous tandem genome amplification events in Yersinia pestis.PloS one · 2025Article
- Stone AgeProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Two Distinct Yersinia pestis Populations Causing Plague among Humans in the West Nile Region of Uganda.PLoS neglected tropical diseases · 2016Article
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13 authors.
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Abstract
The Yersinia pestis chromosome contains a large variety and number of insert sequences that have resulted in frequent chromosome rearrangement events. To identify the chromosomal rearrangement features of Y. pestis strains from five typical plague foci in China and study spontaneous DNA rearrangements potentially stabilized in certain lineages of Y. pestis genomes, we examined the linking mode of locally collinear blocks (LCBs) in 30 Y. pestis strains by a polymerase chain reaction-based method. Our results suggest most strains have relatively stable chromosomal arrangement patterns, and these rearrangement characteristics also have a very close relationship with the geographical origin. In addition, some LCB linking modes are only present in specific strains. We conclude Y. pestis chromosome rearrangement patterns may reflect the genetic features of specific geographical areas and can be applied to distinguish Y. pestis isolates; furthermore, most of the rearrangement events are stable in certain lineages of Y. pestis genomes.
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