ReviewCurrent opinion in pharmacology2014
Duodenal luminal nutrient sensing.
Review in Current opinion in pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Activation profile of the Atlantic salmon (Salmo salar) calcium-sensing receptor (Casr) by selected L-amino acids.Scientific reports · 2025Article
- Comprehensive Treatment of Functional Dyspepsia Using Traditional Chinese Medicine: A Review Based on Pathophysiological Perspectives.Drug design, development and therapy · 2025Review
- Side-Stream Based Marine Solubles From Atlantic Cod (Aquaculture nutrition · 2025Article
- Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats.World journal of gastroenterology · 2022Article
- Uric acid extrarenal excretion: the gut microbiome as an evident yet understated factor in gout development.Rheumatology international · 2022Review
- "Greedy Organs Hypothesis" for sugar and salt in the pathophysiology of non-communicable diseases in relation to sodium-glucose co-transporters in the intestines and the kidney.Metabolism open · 2022Review
- The Role of Leaky Gut in Functional Dyspepsia.Frontiers in neuroscience · 2022Review
- Distribution of α-synuclein in normal human jejunum and its relations with the chemosensory and neuroendocrine system.European journal of histochemistry : EJH · 2021Article
- Mechanisms of Food-Induced Symptom Induction and Dietary Management in Functional Dyspepsia.Nutrients · 2021Review
- Effects of Short-Term Fasting on mRNA Expression of Ghrelin and the Peptide Transporters PepT1 and 2 in Atlantic Salmon (Frontiers in physiology · 2021Article
- New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion.Molecules (Basel, Switzerland) · 2020Article
- Explorative Screening of Bioactivities Generated by Plant-Based Proteins after In Vitro Static Gastrointestinal Digestion.Nutrients · 2020Article
- Duodenal chemosensory system: enterocytes, enteroendocrine cells, and tuft cells.Current opinion in gastroenterology · 2020Review
- Role of the Duodenum in the Pathogenesis of Functional Dyspepsia: A Paradigm Shift.Journal of neurogastroenterology and motility · 2018Review
- FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats.Digestive diseases and sciences · 2017Article
- Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.Histochemistry and cell biology · 2016Article
- Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine.World journal of gastrointestinal pathophysiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The gastrointestinal mucosa is exposed to numerous chemical substances and microorganisms, including macronutrients, micronutrients, bacteria, endogenous ions, and proteins. The regulation of mucosal protection, digestion, absorption and motility is signaled in part by luminal solutes. Therefore, luminal chemosensing is an important mechanism enabling the mucosa to monitor luminal conditions, such as pH, ion concentrations, nutrient quantity, and microflora. The duodenal mucosa shares luminal nutrient receptors with lingual taste receptors in order to detect the five basic tastes, in addition to essential nutrients, and unwanted chemicals. The recent 'de-orphanization' of nutrient sensing G protein-coupled receptors provides an essential component of the mechanism by which the mucosa senses luminal nutrients. In this review, we will update the mechanisms of and underlying physiological and pathological roles in luminal nutrient sensing, with a main focus on the duodenal mucosa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.