ArticleMacromolecular rapid communications2014
Cell-friendly inverse opal-like hydrogels for a spatially separated co-culture system.
Article in Macromolecular rapid communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Engineering Mechanical Microenvironments: Integration of Substrate and Flow Mechanics Reveals the Impact on the Endothelial Glycocalyx.ACS biomaterials science & engineering · 2025Article
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- Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing.Small science · 2024Article
- Tailor-Made Polysaccharides for Biomedical Applications.ACS applied bio materials · 2024Review
- Mitigating Metal-Organic Framework (MOF) Toxicity for Biomedical Applications.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2023Article
- Engineering injectable, biocompatible, and highly elastic bioadhesive cryogels.Materials today. Bio · 2023Article
- Endothelial glycocalyx sensitivity to chemical and mechanical sub-endothelial substrate properties.Frontiers in bioengineering and biotechnology · 2023Article
- Biomaterials Recycling: A Promising Pathway to Sustainability.Frontiers in biomaterials science · 2023Article
- Latest Advances in 3D Bioprinting of Cardiac Tissues.Advanced materials technologies · 2022Article
- Clickable Polysaccharides for Biomedical Applications: A Comprehensive Review.Progress in polymer science · 2022Article
- Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction.Materials today. Bio · 2022Article
- Reversed-engineered human alveolar lung-on-a-chip model.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Augmenting Tendon-to-Bone Repair with Functionally Graded Scaffolds.Advanced healthcare materials · 2021Review
- Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties.Scientific reports · 2020Article
- Hyaluronic acid induces ROCK-dependent amoeboid migration in glioblastoma cells.Biomaterials science · 2020Article
- Electroconductive Hydrogels for Tissue Engineering: Current Status and Future Perspectives.Bioelectricity · 2020Article
- Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation.ACS omega · 2020Article
- Fabrication of Bioactive Inverted Colloidal Crystal Scaffolds Using Expanded Polystyrene Beads.Tissue engineering. Part C, Methods · 2020Article
- Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals.Frontiers in bioengineering and biotechnology · 2020Article
- 3D Hydrogels Containing Interconnected Microchannels of Subcellular Size for Capturing Human PathogenicACS biomaterials science & engineering · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Three-dimensional macroporous scaffolds have extensively been studied for cell-based tissue engineering but their use is mostly limited to mechanical support for cell adhesion and growth on the surface of macropores. Here, a templated fabrication method is described to prepare cell-friendly inverse opal-like hydrogels (IOHs) allowing both cell encapsulation within the hydrogel matrix and cell seeding on the surface of macropores. Ionically crosslinked alginate microbeads and photocrosslinkable biocompatible polymers are used as a sacrificial template and as a matrix, respectively. The alginate microbeads are easily removed by a chelating agent, with minimal toxicity for the encapsulated cells during template removal. The outer surface of macropores in IOHs can also provide a space for cell adherence. The cells encapsulated or attached in IOHs are able to remain viable and to proliferate over time. The elastic modulus and cell-adhesion properties of IOHs can be easily controlled and tuned. Finally, it is demonstrated that IOH can be used to co-culture two distinct cell populations in different spatial positions. This cell-friendly IOH system provides a 3D scaffold for organizing different cell types in a controllable microenvironment to investigate biological processes such as stem cell niches or tumor microenvironments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.