ArticleGenes, brain, and behavior2014
Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease.
Article in Genes, brain, and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 37 citations in OpenAlex.
- Genetics of α-Synuclein: The Prime Pathological Player of Parkinson's Disease.Neurotoxicity research · 2026Review
- Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions.Translational neurodegeneration · 2023Review
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- Longitudinal assessment of motor function following the unilateral intrastriatal 6-hydroxydopamine lesion model in mice.Frontiers in behavioral neuroscience · 2022Article
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- Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila.Disease models & mechanisms · 2021Article
- A Method to QuantifyBio-protocol · 2021Article
- L-DOPA-Induced Dyskinesia in a Genetic Drosophila Model of Parkinson's Disease.Experimental neurobiology · 2020Article
- Differential effects of CuBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2020Article
- Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease.Journal of Parkinson's disease · 2020Review
- Article
- Abundant fish protein inhibits α-synuclein amyloid formation.Scientific reports · 2018Article
- Modeling Parkinson's Disease inFrontiers in neurology · 2018Review
- Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease.PloS one · 2017Article
- Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors.PloS one · 2015Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is a movement neurodegenerative disorder, characterized by bradykinesia, rigidity and tremor, constituting difficulties in walking and abnormal gait. Previous research shows that Drosophila expressing human α-synuclein A30P (A30P) develop deficits in geotaxis climbing; however, geotaxis climbing is a different movement modality from walking. Whether A30P flies would exhibit abnormal walking in a horizontal plane, a measure more relevant to PD, is not known. In this study, we characterized A30P fly walking using a high-speed camera and an automatic behavior tracking system. We found that old but not young A30P flies exhibited walking abnormalities, specifically decreased total moving distance, distance per movement, velocity, angular velocity and others, compared with old control flies. Those features match the definition of bradykinesia. Multivariate analysis further suggested a synergistic effect of aging and A30P, resulting in a distinct pattern of walking deficits, as seen in aged A30P flies. Psychiatric problems are common in PD patients with anxiety affecting 40-69% of patients. Central avoidance is one assessment of anxiety in various animal models. We found old but not young A30P flies exhibited increased centrophobism, suggesting possible elevated anxiety. Here, we report the first quantitative measures of walking qualities in a PD fly model and propose an alternative behavior paradigm for evaluating motor functions apart from climbing assay.
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