ArticleNeurobiology of aging2015
Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Hippocampal connectivity predicting recognition and categorization abilities.Frontiers in cognition · 2026Article
- Relationship between cortical thickness and serotonin 1A receptor binding in bipolar disorder.Translational psychiatry · 2025Article
- Astrocytes, via RTP801, contribute to cognitive decline by disrupting GABAergic-regulated connectivity and driving neuroinflammation in an Alzheimer's disease mouse model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Age-related contextual cueing features are more evident in reaction variability than in reaction time.Quarterly journal of experimental psychology (2006) · 2025Article
- Advancing the modified face name associative memory exam in cognitive aging research: insights into connectomic correlates and task reliability.Frontiers in aging neuroscience · 2025Article
- Longitudinal effects of sex differences and apolipoprotein E genotype on white matter engagement among elderly.Brain communications · 2025Article
- The Impact of Ageing on Episodic Memory Retrieval: How Valence Influences Neural Functional Connectivity.NeuroSci · 2024Article
- Frequency-specific directed connectivity between the hippocampus and parietal cortex during verbal and spatial episodic memory: an intracranial EEG replication.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Intrinsic functional connectivity strength of SuperAgers in the default mode and salience networks: Insights from ADNI.Aging brain · 2024Article
- The relationship between resting-state amplitude fluctuations and memory-related deactivations of the default mode network in young and older adults.Human brain mapping · 2023Article
- Associative memory is more strongly predicted by age-related differences in the prefrontal cortex than medial temporal lobes.Neuroimage. Reports · 2023Article
- Altered Brain Morphometry in Cerebral Small Vessel Disease With Cerebral Microbleeds: An Investigation Combining Univariate and Multivariate Pattern Analyses.Frontiers in neurology · 2022Article
- Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Proteomic and Transcriptomic Analyses Reveal Pathological Changes in the Entorhinal Cortex Region that Correlate Well with Dysregulation of Ion Transport in Patients with Alzheimer's Disease.Molecular neurobiology · 2021Article
- Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults.Alzheimer's research & therapy · 2021Article
- Hippocampal and Parahippocampal Gray Matter Structural Integrity Assessed by Multimodal Imaging Is Associated with Episodic Memory in Old Age.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury.Scientific reports · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
Advanced aging negatively impacts memory performance. Brain aging has been associated with shrinkage in medial temporal lobe structures essential for memory--including hippocampus and entorhinal cortex--and with deficits in default-mode network connectivity. Yet, whether and how these imaging markers are relevant to age-related memory deficits remains a topic of debate. Using a sample of 182 older (age 74.6 ± 6.2 years) and 66 young (age 22.2 ± 3.6 years) participants, this study examined relationships among memory performance, hippocampus volume, entorhinal cortex thickness, and default-mode network connectivity across aging. All imaging markers and memory were significantly different between young and older groups. Each imaging marker significantly mediated the relationship between age and memory performance and collectively accounted for most of the variance in age-related memory performance. Within older participants, default-mode connectivity and hippocampus volume were independently associated with memory. Structural equation modeling of cross-sectional data within older participants suggest that entorhinal thinning may occur before reduced default-mode connectivity and hippocampal volume loss, which in turn lead to deficits in memory performance.
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