Evidence map›Paper›PMID 25113651›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2014

Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy.

Jessica A Cohen, Anna C Mastroianni, Ruth Macklin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jessica A CohenPATH, Seattle, WA, USA. Electronic address: jcohen@path.org.
Anna C MastroianniUniversity of Washington School of Law, Seattle, WA, USA.
Ruth MacklinDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.

Funding

Advancing HIV Research in Pregnancy; ethics and engagementR56AI108368 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LYERLY, ANNE DRAPKIN · 2013 to 2013
$713k
NIAID NIH HHS 1 R56 AI108368-01NIAID NIH HHS R56 AI108368
6 · The paper itself

Abstract

Multipurpose prevention technologies (MPTs) designed to simultaneously prevent pregnancy and HIV could provide urgently needed tools to address unmet sexual and reproductive health needs of women worldwide. Late-stage clinical trials will be complex given the need to demonstrate efficacy for HIV and contraceptive indications simultaneously from a single product. Currently, HIV and pregnancy prevention trials have distinctive design features that will need to be reconciled in MPT trials. This article identifies several ethical issues uniquely associated with this research that will benefit from future deliberation and guidance to ensure that this globally important research can proceed efficiently and expeditiously.

Indexed as

Anti-Infective AgentsAnti-Retroviral AgentsClinical Trials as TopicContraceptionFemaleHIV InfectionsHumansMalePregnancyPrimary PreventionAnti-Infective AgentsAnti-Retroviral AgentsEthicsHIV preventionMultipurpose prevention technologiesPregnancy prevention

Identifiers

PMID25113651
PMCPMC4219999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.