ArticleScientific reports2014
Watching individual molecules flex within lipid membranes using SERS.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Development, Characterization, and Evaluation of Chi-Tn mAb-Functionalized DOTAP-PLGA Hybrid Nanoparticles Loaded with Docetaxel for Lung Cancer Therapy.Pharmaceutics · 2025Article
- Strongly coupled Raman scattering enhancement revealed by scattering-type scanning near-field optical microscopy.Nanophotonics (Berlin, Germany) · 2023Article
- Pushing the limits.Nature reviews. Chemistry · 2022Article
- Structure and Interaction of Ceramide-Containing Liposomes with Gold Nanoparticles as Characterized by SERS and Cryo-EM.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
- Review
- Cascaded nanooptics to probe microsecond atomic-scale phenomena.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Out-of-Plane Nanoscale Reorganization of Lipid Molecules and Nanoparticles Revealed by Plasmonic Spectroscopy.The journal of physical chemistry letters · 2020Article
- Present and Future of Surface-Enhanced Raman Scattering.ACS nano · 2020Article
- Extreme nanophotonics from ultrathin metallic gaps.Nature materials · 2019Review
- Probing Membrane Receptor-Ligand Specificity with Surface- and Tip- Enhanced Raman Scattering.Analytical chemistry · 2017Article
- Surface-enhanced Raman scattering of self-assembled thiol monolayers and supported lipid membranes on thin anodic porous alumina.Beilstein journal of nanotechnology · 2017Article
- Reproducible Ultrahigh SERS Enhancement in Single Deterministic Hotspots Using Nanosphere-Plane Antennas Under Radially Polarized Excitation.Scientific reports · 2016Article
- SERS of Individual Nanoparticles on a Mirror: Size Does Matter, but so Does Shape.The journal of physical chemistry letters · 2016Article
- Article
- Monitoring morphological changes in 2D monolayer semiconductors using atom-thick plasmonic nanocavities.ACS nano · 2015Article
- Nanooptics of molecular-shunted plasmonic nanojunctions.Nano letters · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Interrogating individual molecules within bio-membranes is key to deepening our understanding of biological processes essential for life. Using Raman spectroscopy to map molecular vibrations is ideal to non-destructively 'fingerprint' biomolecules for dynamic information on their molecular structure, composition and conformation. Such tag-free tracking of molecules within lipid bio-membranes can directly connect structure and function. In this paper, stable co-assembly with gold nano-components in a 'nanoparticle-on-mirror' geometry strongly enhances the local optical field and reduces the volume probed to a few nm(3), enabling repeated measurements for many tens of minutes on the same molecules. The intense gap plasmons are assembled around model bio-membranes providing molecular identification of the diffusing lipids. Our experiments clearly evidence measurement of individual lipids flexing through telltale rapid correlated vibrational shifts and intensity fluctuations in the Raman spectrum. These track molecules that undergo bending and conformational changes within the probe volume, through their interactions with the environment. This technique allows for in situ high-speed single-molecule investigations of the molecules embedded within lipid bio-membranes. It thus offers a new way to investigate the hidden dynamics of cell membranes important to a myriad of life processes.
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Registered trials
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