Observational studyJournal of nephrology2015
Parathyroid hormone may be an early predictor of low serum hemoglobin concentration in patients with not advanced stages of chronic kidney disease.
Observational study in Journal of nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The effect of vitamin D supplementation on hemoglobin concentration: a systematic review and meta-analysis.Nutrition journal · 2020Pooled it
- Early vitamin AD supplementation reduces transfusion needs in preterm infants: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Dietary nutrient intake and nutritional status in maintenance hemodialysis patients: a multicenter cross-sectional survey.Renal failure · 2024Article
- Dietary knowledge-attitude-practice status in hemodialysis patients: a latent profile analysis.BMC public health · 2024Article
- Inverse Relationship between Mean Corpuscular Volume and T-Score in Chronic Dialysis Patients.Medicina (Kaunas, Lithuania) · 2022Article
- Bone Mineral Density Changes in Long-Term Kidney Transplant Recipients: A Real-Life Cohort Study of Native Vitamin D Supplementation.Nutrients · 2022Observational
- Association between Serum Magnesium and Hemoglobin in Patients with Primary Hyperparathyroidism.International journal of endocrinology · 2021Article
- Treatment of hyperphosphatemia: the dangers of high PTH levels.Pediatric nephrology (Berlin, Germany) · 2020Review
- The Role of Prognostic and Predictive Biomarkers for Assessing Cardiovascular Risk in Chronic Kidney Disease Patients.BioMed research international · 2020Review
- Factors associated with erythropoiesis-stimulating agent hyporesponsiveness anemia in chronic kidney disease patients.Hematology reports · 2019Article
- Hypocalcemia-based prediction of hungry bone syndrome after parathyroidectomy in hemodialysis patients with refractory secondary hyperparathyroidism.The Journal of international medical research · 2018Article
- Review
- Vitamin D and anemia: insights into an emerging association.Current opinion in endocrinology, diabetes, and obesity · 2015Review
- The resolution of anemia after curative parathyroidectomy is sustained even after a decade.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParathyroid hormone (PTH) has been associated with anemia only in dialysis patients with severe hyperparathyroidism. Whether an association between PTH and hemoglobin also exists in patients with chronic kidney disease not on dialysis (CKD-patients) is still unclear. In this study we evaluated the association between PTH and hemoglobin in CKD-patients without severe secondary hyperparathyroidism.
methodsHospitalized patients and outpatients (N = 979) were retrospectively evaluated and categorized according to PTH quartile and serum hemoglobin (<12.0, <11.0, <10.0 g/dl). Gender, diabetes, glomerular filtration rate (GFR), hemoglobin, PTH, markers of mineral metabolism, inflammation, iron status and nutrition were variables of adjustment in univariate and multivariate analysis.
resultsAn inverse association (p = 0.001) was observed between PTH and hemoglobin in patients as a whole, in diabetics, and in patients with GFR ≤60 ml/min. PTH was the single predictor of low hemoglobin in patients as a whole (unstandardized beta -2.12; p = 0.005), in diabetics (unstandardized beta -8.86; p = 0.007) and in patients with GFR ≤60 ml/min (unstandardized beta -2.52; p = 0.006). For each increase of quartile of PTH the risk of having hemoglobin level <10.0 mg/dl was more than doubled [hazard ratio (HR) 2.79, 95% confidence interval (CI) 2.00-3.88; p = 0.001]. The receiver operating characteristic curve showed that PTH ≥122 pg/ml had 67% sensitivity and 75% specificity in predicting hemoglobin level <10.0 g/dl with area under the curve of 0.758 (95% CI 0.73-0.78).
conclusionsThis study shows a significant inverse association between PTH and hemoglobin levels across the whole spectrum of non-dialysis CKD and a doubled risk of having serum hemoglobin <10.0 mg/dl in the absence of severely deranged PTH concentration. These findings may have clinical relevance in ascertaining the cause of unexplained low hemoglobin levels in CKD-patients.
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