ArticleMolecular neurobiology2015
Identification and Expression of Acetylcholinesterase in Octopus vulgaris Arm Development and Regeneration: a Conserved Role for ACHE?
Article in Molecular neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- The best defense is a good offense: Anti-predator behavior of the common octopus (Ecology and evolution · 2024Article
- Transcriptome-wide selection and validation of a solid set of reference genes for gene expression studies in the cephalopod molluskFrontiers in molecular neuroscience · 2023Article
- Deciphering regeneration through non-model animals: A century of experiments on cephalopod mollusks and an outlook at the future.Frontiers in cell and developmental biology · 2022Review
- Imaging Arm Regeneration: Label-Free Multiphoton Microscopy to Dissect the Process inFrontiers in cell and developmental biology · 2022Article
- Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration.Signal transduction and targeted therapy · 2021Review
- Review
- Synapsins are expressed at neuronal and non-neuronal locations in Octopus vulgaris.Scientific reports · 2019Article
- Motor control pathways in the nervous system of Octopus vulgaris arm.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Article
- Genetic and Epigenetic Control of CDKN1C Expression: Importance in Cell Commitment and Differentiation, Tissue Homeostasis and Human Diseases.International journal of molecular sciences · 2018Review
- Nerve regeneration in the cephalopod molluscJournal of the Royal Society, Interface · 2018Article
- Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle.International journal of molecular sciences · 2018Review
- Cephalopod Tissue Regeneration: Consolidating Over a Century of Knowledge.Frontiers in physiology · 2018Review
- A Novel Approach to Primary Cell Culture forFrontiers in physiology · 2018Article
- Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration.Frontiers in cell and developmental biology · 2017Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylcholinesterase (ACHE) is a glycoprotein with a key role in terminating synaptic transmission in cholinergic neurons of both vertebrates and invertebrates. ACHE is also involved in the regulation of cell growth and morphogenesis during embryogenesis and regeneration acting through its non-cholinergic sites. The mollusk Octopus vulgaris provides a powerful model for investigating the mechanisms underlying tissue morphogenesis due to its high regenerative power. Here, we performed a comparative investigation of arm morphogenesis during adult arm regeneration and embryonic arm development which may provide insights on the conserved ACHE pathways. In this study, we cloned and characterized O. vulgaris ACHE, finding a single highly conserved ACHE hydrophobic variant, characterized by prototypical catalytic sites and a putative consensus region for a glycosylphosphatidylinositol (GPI)-anchor attachment at the COOH-terminus. We then show that its expression level is correlated to the stage of morphogenesis in both adult and embryonic arm. In particular, ACHE is localized in typical neuronal sites when adult-like arm morphology is established and in differentiating cell locations during the early stages of arm morphogenesis. This possibility is also supported by the presence in the ACHE sequence and model structure of both cholinergic and non-cholinergic sites. This study provides insights into ACHE conserved roles during processes of arm morphogenesis. In addition, our modeling study offers a solid basis for predicting the interaction of the ACHE domains with pharmacological blockers for in vivo investigations. We therefore suggest ACHE as a target for the regulation of tissue morphogenesis.
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