ArticleEpilepsy & behavior : E&B2014
Brief postnatal exposure to phenobarbital impairs passive avoidance learning and sensorimotor gating in rats.
Article in Epilepsy & behavior : E&B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Padsevonil suppresses seizures without inducing cell death in neonatal rats.Pharmacological reports : PR · 2024Article
- Anti-seizure medication-induced developmental cell death in neonatal rats is unaltered by history of hypoxia.Epilepsy research · 2024Article
- A single exposure to brivaracetam or perampanel does not cause cell death in neonatal rats.Frontiers in pediatrics · 2024Article
- Early life phenobarbital exposure dysregulates the hippocampal transcriptome.Frontiers in pharmacology · 2024Article
- Current Insights Regarding Intestinal Failure-Associated Liver Disease (IFALD): A Narrative Review.Nutrients · 2023Review
- The outcome of early life status epilepticus-lessons from laboratory animals.Epilepsia open · 2023Article
- Effects of Maternal Use of Antiseizure Medications on Child Development.Neurologic clinics · 2022Review
- Preclinical efficacy of cannabidiol for the treatment of early-life seizures.Pharmacological reports : PR · 2022Article
- Effect of Phenobarbital on Elevated Direct Bilirubin Concentrations in Neonates and Infants in the Neonatal Intensive Care Unit.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Neonatal Seizures and Purinergic Signalling.International journal of molecular sciences · 2020Review
- Status Epilepticus in the Neonate: Updates in Treatment Strategies.Current treatment options in neurology · 2019Review
- Outpatient Pharmacotherapy for Neonatal Abstinence Syndrome.The Journal of pediatrics · 2018Article
- Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.Scientific reports · 2018Article
- Ursodeoxycholic acid versus phenobarbital for cholestasis in the Neonatal Intensive Care Unit.BMC pediatrics · 2018Article
- Evaluation of Acute and Chronic Effects of D-Galactose on Memory and Learning in Wistar Rats.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2018Article
- Neonatal phenobarbital exposure disrupts GABAergic synaptic maturation in rat CA1 neurons.Epilepsia · 2018Article
- Impact of Traumatic Brain Injury on Neurogenesis.Frontiers in neuroscience · 2018Article
- Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.Brain research · 2016Article
- Anticonvulsant drug-induced cell death in the developing white matter of the rodent brain.Epilepsia · 2016Article
- Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats.Epilepsy & behavior : E&B · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Phenobarbital is the most commonly utilized drug for the treatment of neonatal seizures. However, mounting preclinical evidence suggests that even brief exposure to phenobarbital in the neonatal period can induce neuronal apoptosis, alterations in synaptic development, and long-lasting changes in behavioral functions. In the present report, we treated neonatal rat pups with phenobarbital and evaluated behavior in adulthood. Pups were treated initially with a loading dose (80 mg/kg) on postnatal day (P)7 and with a lower dose (40 mg/kg) on P8 and P9. We examined sensorimotor gating (prepulse inhibition), passive avoidance, and conditioned place preference for cocaine when the animals reached adulthood. Consistent with our previous reports, we found that three days of neonatal exposure to phenobarbital significantly impaired prepulse inhibition compared with vehicle-exposed control animals. Using a step-though passive avoidance paradigm, we found that animals exposed to phenobarbital as neonates and tested as adults showed significant deficits in passive avoidance retention compared with matched controls, indicating impairment in associative memory and/or recall. Finally, we examined place preference conditioning in response to cocaine. Phenobarbital exposure did not alter the normal conditioned place preference associated with cocaine exposure. Our findings expand the profile of behavioral toxicity induced by phenobarbital.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.