ArticleJournal of bacteriology2014
Competence for genetic transformation in Streptococcus pneumoniae: mutations in σA bypass the comW requirement.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Cyclic Di-AMP Affects Cell Membrane Integrity of Streptococcus pneumoniae.Molecular microbiology · 2025Article
- Fever-like temperature bursts promote competence development via an HtrA-dependent pathway in Streptococcus pneumoniae.PLoS genetics · 2023Article
- Article
- Recognition of Streptococcal Promoters by the Pneumococcal SigA Protein.Frontiers in molecular biosciences · 2021Article
- ComWΔ6 Stimulates Transcription of Pneumococcal Competence GenesFrontiers in molecular biosciences · 2020Article
- The pneumococcal σThe Journal of biological chemistry · 2019Article
- Competence inFrontiers in cellular and infection microbiology · 2019Review
- Function of BriC peptide in the pneumococcal competence and virulence portfolio.PLoS pathogens · 2018Article
- Dynamic Modeling ofFrontiers in microbiology · 2018Article
- Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans.Genes · 2017Review
- Competence for Genetic Transformation in Streptococcus pneumoniae: Mutations in σA Bypass the ComW Requirement for Late Gene Expression.Journal of bacteriology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Competence for genetic transformation in the genus Streptococcus depends on an alternative sigma factor, σ(X), for coordinated synthesis of 23 proteins, which together establish the X state by permitting lysis of incompetent streptococci, uptake of DNA fragments, and integration of strands of that DNA into the resident genome. Initiation of transient accumulation of high levels of σ(X) is coordinated between cells by transcription factors linked to peptide pheromone signals. In Streptococcus pneumoniae, elevated σ(X) is insufficient for development of full competence without coexpression of a second competence-specific protein, ComW. ComW, shared by eight species in the Streptococcus mitis and Streptococcus anginosus groups, is regulated by the same pheromone circuit that controls σ(X), but its role in expression of the σ(X) regulon is unknown. Using the strong, but not absolute, dependence of transformation on comW as a selective tool, we collected 27 independent comW bypass mutations and mapped them to 10 single-base transitions, all within rpoD, encoding the primary sigma factor subunit of RNA polymerase, σ(A). Eight mapped to sites in rpoD region 4 that are implicated in interaction with the core β subunit, indicating that ComW may act to facilitate competition of the alternative sigma factor σ(X) for access to core polymerase.
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Registered trials
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