ArticleJournal of bacteriology2014
The disulfide bonding system suppresses CsgD-independent cellulose production in Escherichia coli.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
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- Exploring reductive stress as a regulation approach foriScience · 2025Article
- The Determination, Monitoring, Molecular Mechanisms and Formation of Biofilm in E. coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Review
- Recent advances and perspectives in nucleotide second messenger signaling in bacteria.microLife · 2023Review
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- The Diguanylate Cyclase YfiN of Pseudomonas aeruginosa Regulates Biofilm Maintenance in Response to Peroxide.Journal of bacteriology · 2022Article
- The ever-expanding world of bacterial cyclic oligonucleotide second messengers.Current opinion in microbiology · 2021Review
- Multicellular String-Like Structure Formation byFrontiers in microbiology · 2020Article
- The y-ome defines the 35% of Escherichia coli genes that lack experimental evidence of function.Nucleic acids research · 2019Article
- Tannic and gallic acids alter redox-parameters of the medium and modulate biofilm formation.AIMS microbiology · 2019Article
- Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP phosphodiesterase.The EMBO journal · 2018Article
- Thiol Starvation Induces Redox-Mediated Dysregulation of Escherichia coli Biofilm Components.Journal of bacteriology · 2018Article
- HmsC ControlsFrontiers in cellular and infection microbiology · 2017Article
- The Catabolite Repressor Protein-Cyclic AMP Complex Regulates csgD and Biofilm Formation in Uropathogenic Escherichia coli.Journal of bacteriology · 2016Article
- Article
- Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system.Protein & cell · 2016Article
- Systematic Nomenclature for GGDEF and EAL Domain-Containing Cyclic Di-GMP Turnover Proteins of Escherichia coli.Journal of bacteriology · 2016Article
- Genome-Based Comparison of Cyclic Di-GMP Signaling in Pathogenic and Commensal Escherichia coli Strains.Journal of bacteriology · 2016Article
- Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The bacterial extracellular matrix encases cells and protects them from host-related and environmental insults. The Escherichia coli master biofilm regulator CsgD is required for the production of the matrix components curli and cellulose. CsgD activates the diguanylate cyclase AdrA, which in turn stimulates cellulose production through cyclic di-GMP (c-di-GMP). Here, we identified and characterized a CsgD- and AdrA-independent cellulose production pathway that was maximally active when cultures were grown under reducing conditions or when the disulfide bonding system (DSB) was compromised. The CsgD-independent cellulose activation pathway was dependent on a second diguanylate cyclase, called YfiN. c-di-GMP production by YfiN was repressed by the periplasmic protein YfiR, and deletion of yfiR promoted CsgD-independent cellulose production. Conversely, when YfiR was overexpressed, cellulose production was decreased. Finally, we found that YfiR was oxidized by DsbA and that intraprotein YfiR disulfide bonds stabilized YfiR in the periplasm. Altogether, we showed that reducing conditions and mutations in the DSB system caused hyperactivation of YfiN and subsequent CsgD-independent cellulose production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.