ArticleEuropean journal of nuclear medicine and molecular imaging2015
Targeting post-infarct inflammation by PET imaging: comparison of (68)Ga-citrate and (68)Ga-DOTATATE with (18)F-FDG in a mouse model.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 69 citations in OpenAlex.
- Molecular imaging of immune and fibrosis targets to guide therapy for repair after myocardial infarction.Nature reviews. Cardiology · 2026Review
- Synthesis and preliminary evaluation of cardiac imaging with [RSC pharmaceutics · 2025Article
- Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer.Npj imaging · 2024Article
- Imaging Inflammation Past, Present, and Future: Focus on Cardioimmunology.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Biomedical Imaging in Experimental Models of Cardiovascular Disease.Circulation research · 2022Review
- Comparison of transient and permanent LAD ligation in mice using 18F-FDG PET imaging.Annals of nuclear medicine · 2022Article
- Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation.Scientific reports · 2022Article
- Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Fully Automated Macro- and Microfluidic Production of [Molecules (Basel, Switzerland) · 2022Article
- Nuclear Molecular Imaging of Cardiac Remodeling after Myocardial Infarction.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Dissecting the target leukocyte subpopulations of clinically relevant inflammation radiopharmaceuticals.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Molecular Imaging Using Cardiac PET/CT: Opportunities to Harmonize Diagnosis and Therapy.Current cardiology reports · 2021Review
- Imaging Inflammation with Positron Emission Tomography.Biomedicines · 2021Review
- Comparison of metabolic and functional parameters using cardiac 18F-FDG-PET in early to mid-adulthood male and female mice.EJNMMI research · 2021Article
- Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [Theranostics · 2021Article
- Molecular imaging of inflammation crosstalk along the cardio-renal axis following acute myocardial infarction.Theranostics · 2021Article
- Accuracy of cardiac functional parameters measured from gated radionuclide myocardial perfusion imaging in mice.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Article
- Research Progress of [Molecular imaging and biology · 2020Review
- PET imaging of macrophages in cardiovascular diseases.American journal of translational research · 2020Review
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
unlabelledImaging of inflammation early after myocardial infarction (MI) is a promising approach to the guidance of novel molecular interventions that support endogenous healing processes. (18)F-FDG PET has been used, but may be complicated by physiological myocyte uptake. We evaluated the potential of two alternative imaging targets: lactoferrin binding by (68)Ga-citrate and somatostatin receptor binding by (68)Ga-DOTATATE.
methodsC57Bl/6 mice underwent permanent coronary artery ligation. Serial PET imaging was performed 3 - 7 days after MI using (68)Ga-citrate, (68)Ga-DOTATATE, or (18)F-FDG with ketamine/xylazine suppression of myocyte glucose uptake. Myocardial perfusion was evaluated by (13)N-ammonia PET and cardiac geometry by contrast-enhanced ECG-gated CT.
resultsMice exhibited a perfusion defect of 30 - 40% (of the total left ventricle) with apical anterolateral wall akinesia and thinning on day 7 after MI. (18)F-FDG with ketamine/xylazine suppression demonstrated distinct uptake in the infarct region, as well as in the border zone and remote myocardium. The myocardial standardized uptake value in MI mice was significantly higher than in healthy mice under ketamine/xylazine anaesthesia (1.9 ± 0.4 vs. 1.0 ± 0.1). (68)Ga images exhibited high blood pool activity with no specific myocardial uptake up to 90 min after injection (tissue-to-blood contrast 0.9). (68)Ga-DOTATATE was rapidly cleared from the blood, but myocardial SUV was very low (0.10 ± 0.03).
conclusionNeither (68)Ga nor (68)Ga-DOTATATE is a useful alternative to (18)F-FDG for PET imaging of myocardial inflammation after MI in mice. Among the three tested approaches, (18)F-FDG with ketamine/xylazine suppression of cardiomyocyte uptake remains the most practical imaging marker of post-infarct inflammation.
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