ArticlePloS one2014
Effects of aging on genioglossus motor units in humans.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Sleep-disordered breathing as a risk factor for sarcopenia in the elderly: a narrative review.Sleep & breathing = Schlaf & Atmung · 2026Review
- The evidence for old age motor neuron death: A scoping review.Physiological reports · 2026Article
- Abnormalities in the genioglossus muscle and its neuromuscular synapse in leptin-deficient male mice.Skeletal muscle · 2025Article
- Obstructive sleep apnea in community-dwelling polio survivors: a 5-year longitudinal follow-up study.Frontiers in neurology · 2025Article
- The impact of daytime transoral neuromuscular stimulation on upper airway physiology - A mechanistic clinical investigation.Physiological reports · 2022Article
- Clinical, polysomnographic, and cephalometric features of obstructive sleep apnea with AHI over 100.Sleep & breathing = Schlaf & Atmung · 2021Article
- Human motor unit characteristics of the superior trapezius muscle with age-related comparisons.Journal of neurophysiology · 2019Article
- Effects of a Combined Community Exercise Program in Obstructive Sleep Apnea Syndrome: A Randomized Clinical Trial.Journal of clinical medicine · 2019Article
- The effect of aging on drug-induced sleep endoscopy findings.The Laryngoscope · 2018Article
- Article
- Neurogenic changes in the upper airway of obstructive sleep apnoea.Current neurology and neuroscience reports · 2015Review
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Corrections and comments
- Erratum issued
Authors and funding
6 authors at 6 institutions in 3 countries.
Funding
Abstract
The genioglossus is a major upper airway dilator muscle thought to be important in obstructive sleep apnea pathogenesis. Aging is a risk factor for obstructive sleep apnea although the mechanisms are unclear and the effects of aging on motor unit remodeled in the genioglossus remains unknown. To assess possible changes associated with aging we compared quantitative parameters related to motor unit potential morphology derived from EMG signals in a sample of older (n = 11; >55 years) versus younger (n = 29; <55 years) adults. All data were recorded during quiet breathing with the subjects awake. Diagnostic sleep studies (Apnea Hypopnea Index) confirmed the presence or absence of obstructive sleep apnea. Genioglossus EMG signals were analyzed offline by automated software (DQEMG), which estimated a MUP template from each extracted motor unit potential train (MUPT) for both the selective concentric needle and concentric needle macro (CNMACRO) recorded EMG signals. 2074 MUPTs from 40 subjects (mean±95% CI; older AHI 19.6±9.9 events/hr versus younger AHI 30.1±6.1 events/hr) were extracted. MUPs detected in older adults were 32% longer in duration (14.7±0.5 ms versus 11.1±0.2 ms; P = 0.05), with similar amplitudes (395.2±25.1 µV versus 394.6±13.7 µV). Amplitudes of CNMACRO MUPs detected in older adults were larger by 22% (62.7±6.5 µV versus 51.3±3.0 µV; P<0.05), with areas 24% larger (160.6±18.6 µV.ms versus 130.0±7.4 µV.ms; P<0.05) than those detected in younger adults. These results confirm that remodeled motor units are present in the genioglossus muscle of individuals above 55 years, which may have implications for OSA pathogenesis and aging related upper airway collapsibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.