ArticlePloS one2014
Pleiotropic functions for transcription factor zscan10.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Genes as Genome Stabilizers in Pluripotent Stem Cells.Advances in experimental medicine and biology · 2025Review
- ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations.Brain : a journal of neurology · 2024Article
- A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels.Acta neuropathologica communications · 2024Article
- Article
- Vitamin E Deficiency Disrupts Gene Expression Networks during Zebrafish Development.Nutrients · 2021Article
- Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma.Scientific reports · 2020Article
- Genome-wide assessment of DNA methylation in mouse oocytes reveals effects associated with in vitro growth, superovulation, and sexual maturity.Clinical epigenetics · 2019Article
- Quantitative Single-Cell Transcript Assessment of Biomarkers Supports Cellular Heterogeneity in the Bovine IVD.Veterinary sciences · 2019Article
- ZSCAN10 promotes cell proliferation, upregulates OCT4 expression, and activates Wnt/β-catenin signaling in glioma.International journal of clinical and experimental pathology · 2019Article
- Potential biomarkers of the mature intervertebral disc identified at the single cell level.Journal of anatomy · 2019Article
- Transcriptome variations among human embryonic stem cell lines are associated with their differentiation propensity.PloS one · 2018Article
- NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle.Scientific reports · 2017Article
- Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci.Human molecular genetics · 2017Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
36 authors at 7 institutions in 3 countries.
Petra KrausStem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore; Department of Biology, Clarkson University, Potsdam, New York, United States of America.
Sivakamasundari VStem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.
Hong Bing YuStem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.
Xing XingStem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.
Siew Lan LimStem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.
Thure AdlerGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Juan Antonio Aguilar PimentelGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Klinikum rechts der Isar der Technischen Universität München, Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Munich, Germany.
Lore BeckerGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Alexander BohlaGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Lillian GarrettGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Wolfgang HansGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Sabine M HölterGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Eva JanasGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Kristin MorethGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Cornelia PrehnGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Oliver PukGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Birgit RathkolbGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany.
Jan RozmanGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Jerzy AdamskiGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Raffi BekeredjianGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine III, Division of Cardiology, University of Heidelberg, Heidelberg, Germany.
Dirk H BuschGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Microbiology, Immunology, and Hygiene, Technische Universität München, Munich, Germany.
Jochen GrawGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Martin KlingensporGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Molecular Nutritional Medicine, Else Kröner-Fresenius Center, Technische Universität München, Freising-Weihenstephan, Germany.
Thomas KlopstockGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, Munich, Germany.
Frauke NeffGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Markus OllertGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Klinikum rechts der Isar der Technischen Universität München, Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Munich, Germany.
Tobias StoegerGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Ali Önder YildrimGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Oliver EickelbergGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Eckhard WolfGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany.
Wolfgang WurstGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Chair of Developmental Biology, Technische Universität München, Freising-Weihenstephan, Germany; Max Planck Institute of Psychiatry, Munich, Germany; Deutsches Institut für Neurodegenerative Erkrankungen Site Munich, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany.
Helmut FuchsGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Valérie Gailus-DurnerGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Martin Hrabě de AngelisGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Chair of Experimental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany; Member of German Center for Diabetes Research, Neuherberg, Germany.
Thomas LufkinStem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore; Department of Biology, Clarkson University, Potsdam, New York, United States of America.
Lawrence W StantonStem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.
Helmholtz Zentrum München · DEGenome Institute of Singapore · SGLudwig-Maximilians-Universität München · DEMünchen Klinik · DEClarkson University · USFresenius (Germany) · DEMunich Cluster for Systems Neurology · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof.
Indexed as
Genetic PleiotropyAnimalsBehavior, AnimalBody WeightBone and BonesBone DensityCodon, InitiatorEyeFemaleGene Expression RegulationHomozygoteMaleMiceMutationOrgan SizePluripotent Stem CellsCodon, InitiatorTranscription FactorsZscan10 protein, mouse
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