Evidence map›Paper›PMID 25111691›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2014

Merkel cell carcinoma expresses vasculogenic mimicry: demonstration in patients and experimental manipulation in xenografts.

Cecilia Lezcano, Sonja Kleffel, Nayoung Lee, Allison R Larson, Qian Zhan, Andrew DoRosario, Linda C Wang, Tobias Schatton, George F Murphy

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Phenotypic diversity of patient-derived melanoma populations in stem cell medium.Laboratory investigation; a journal of technical methods and pathology · 2015
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Cecilia LezcanoDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Sonja Kleffel1] Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA [2] Harvard Medical School, Boston, MA, USA.
Nayoung Lee1] Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA [2] Harvard Medical School, Boston, MA, USA.
Allison R Larson1] Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA [2] Harvard Medical School, Boston, MA, USA.
Qian Zhan1] Harvard Medical School, Boston, MA, USA [2] Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Andrew DoRosario1] Harvard Medical School, Boston, MA, USA [2] Center for Cutaneous Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA.
Linda C WangInstitute for Cancer Care, Mercy Medical Center, Baltimore, MD, USA.
Tobias Schatton1] Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA [2] Harvard Medical School, Boston, MA, USA [3] Transplantation Research Center, Children's Hospital, Boston, MA, USA.
George F Murphy1] Harvard Medical School, Boston, MA, USA [2] Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USMercy Medical Center · USUniversity of Pittsburgh Medical Center · US

Funding

Targeting Raf in Melanoma: Mechanisms for Effect & Resistance & Opportunities forP50CA093683 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLUB, TODD R. · 2001 to 2012
$25.8M
NCI NIH HHS NIH-P50 CA93683NCI NIH HHS P50 CA093683NCI NIH HHS R01 CA58467
6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is a highly virulent cutaneous neoplasm that, like melanoma, is a frequent cause of patient morbidity and mortality. The cellular mechanisms responsible for the aggressive behavior of MCC remain unknown. Vasculogenic mimicry (VM) is a phenomenon associated with cancer virulence, including in melanoma, whereby anastomosing laminin networks form in association with tumor cells that express certain endothelial genes. To determine whether VM is a factor in MCC, we employed a relevant xenograft model using two independent human MCC lines. Experimentally induced tumors were remarkably similar histologically to patient MCC, and both contained laminin networks associated with vascular endothelial-cadherin (CD144) and vascular endothelial growth factor receptor 1, as well as Nodal expression typical of VM in melanoma. Moreover, two established chemotherapeutic agents utilized for human MCC, etoposide and carboplatin, induced necrosis in xenografts on systemic administration while enriching for laminin networks in apparently resistant viable tumor regions that persisted. These findings for the first time establish VM-like laminin networks as a biomarker in MCC, demonstrate the experimental utility of the MCC xenograft model, and suggest that VM-rich regions of MCC may be refractory to conventional chemotherapeutic agents.

Indexed as

Neovascularization, PathologicAgedAged, 80 and overAnimalsAntineoplastic Agents, PhytogenicCarboplatinCarcinoma, Merkel CellCell Line, TumorEtoposideHumansHuman Umbilical Vein Endothelial CellsLymph NodesMice, KnockoutMiddle AgedNeoplasm InvasivenessNeoplasm TransplantationAntineoplastic Agents, PhytogenicCarboplatinEtoposide

Identifiers

PMID25111691
PMCPMC4236190
OpenAlexW2140754975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.