ArticlePloS one2014
Colorectal cancers mimic structural organization of normal colonic crypts.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Fluctuating DNA methylation sites encode colorectal tumour growth history.bioRxiv : the preprint server for biology · 2026Article
- Impact of gross tumor morphology on the clinical outcomes of colon cancer: multicenter retrospective cohort study.International journal of colorectal disease · 2026Article
- Pleiotropic effects of all-trans retinoic acid in attenuating the hallmarks of colorectal cancer- challenges and scope of differentiation therapy.Cancer gene therapy · 2026Review
- Review
- Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions.International journal of molecular sciences · 2022Article
- The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease.Scientific reports · 2021Article
- Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell.Cancers · 2021Review
- Colorectal Adenomas-Genetics and Searching for New Molecular Screening Biomarkers.International journal of molecular sciences · 2020Review
- Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments.Scientific reports · 2020Article
- Review
- Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.The Journal of pathology · 2019Article
- Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium.Scientific reports · 2019Article
- Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer.The Journal of experimental medicine · 2018Article
- Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer.Nature communications · 2017Article
- Visualization and targeting of LGR5Nature · 2017Article
- Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis.Molecular medicine reports · 2016Article
- CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer.Oncotarget · 2016Article
- The role of the calcium-sensing receptor in gastrointestinal inflammation.Seminars in cell & developmental biology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colonic crypts are stereotypical structures with distinct stem cell, proliferating, and differentiating compartments. Colorectal cancers derive from colonic crypt epithelia but, in contrast, form morphologically disarrayed glands. In this study, we investigated to which extent colorectal cancers phenocopy colonic crypt architecture and thus preserve structural organization of the normal intestinal epithelium. A subset of colon cancers showed crypt-like compartments with high WNT activity and nuclear β-Catenin at the leading tumor edge, adjacent proliferation, and enhanced Cytokeratin 20 expression in most differentiated tumor epithelia of the tumor center. This architecture strongly depended on growth conditions, and was fully reproducible in mouse xenografts of cultured and primary colon cancer cells. Full crypt-like organization was associated with low tumor grade and was an independent prognostic marker of better survival in a collection of 221 colorectal cancers. Our findings suggest that full activation of preserved intestinal morphogenetic programs in colon cancer requires in vivo growth environments. Furthermore, crypt-like architecture was linked with less aggressive tumor biology, and may be useful to improve current colon cancer grading schemes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.