Evidence map›Paper›PMID 25111142›Full record

ArticlePloS one2014

Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable Haemophilus influenzae.

Susan J Pizzutto, Stephanie T Yerkovich, John W Upham, Belinda J Hales, Wayne R Thomas, Anne B Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 52 citations in OpenAlex.

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  10. COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of NontypeableInternational journal of chronic obstructive pulmonary disease · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Susan J PizzuttoMenzies School of Health Research, Charles Darwin University, Brinkin, Northern Territory, Australia.
Stephanie T YerkovichMenzies School of Health Research, Charles Darwin University, Brinkin, Northern Territory, Australia; Queensland Lung Transplant Service, The Prince Charles Hospital, Chermside, Queensland, Australia; School of Medicine, The University of Queensland, St Lucia, Queensland, Australia.
John W UphamSchool of Medicine, The University of Queensland, St Lucia, Queensland, Australia; Department of Respiratory Medicine, Princess Alexandra Hospital, Wooloongabba, Queensland, Australia.
Belinda J HalesTelethon Kids Institute, The University of Western Australia, Crawley, Western Australia, Australia.
Wayne R ThomasTelethon Kids Institute, The University of Western Australia, Crawley, Western Australia, Australia.
Anne B ChangMenzies School of Health Research, Charles Darwin University, Brinkin, Northern Territory, Australia; The Department of Respiratory Medicine, Royal Children's Hospital, Herston, Queensland, Australia; Queensland Children's Medical Research Institute, Royal Children's Hospital, Herston, Queensland, Australia.
Charles Darwin University · AUThe University of Western Australia · AUChildren's Medical Research Institute · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic suppurative lung disease (CSLD) is characterized by the presence of a chronic wet or productive cough and recurrent lower respiratory infections. The aim of this study was to identify features of innate, cell-mediated and humoral immunity that may increase susceptibility to respiratory infections in children with CSLD. Because non-typeable Haemophilus influenzae (NTHi) is commonly isolated from the airways in CSLD, we examined immune responses to this organism in 80 age-stratified children with CSLD and compared their responses with 51 healthy control children. Cytokines involved in the generation and control of inflammation (IFN-γ, IL-13, IL-5, IL-10 at 72 hours and TNFα, IL-6, IL-10 at 24 hours) were measured in peripheral blood mononuclear cells challenged in vitro with live NTHi. We also measured circulating IgG subclass antibodies (IgG1 and IgG4) to two H. influenzae outer membrane proteins, P4 and P6. The most notable finding was that PBMC from children with CSLD produced significantly less IFN-γ in response to NTHi than healthy control children whereas mitogen-induced IFN-γ production was similar in both groups. Overall there were minor differences in innate and humoral immune responses between CSLD and control children. This study demonstrates that children with chronic suppurative lung disease have an altered systemic cell-mediated immune response to NTHi in vitro. This deficient IFN-γ response may contribute to increased susceptibility to NTHi infections and the pathogenesis of CSLD in children.

Indexed as

Antibodies, BacterialAntibody SpecificityChildChronic DiseaseDisease SusceptibilityFemaleHaemophilus influenzaeHumansImmunity, InnateInfantInterferon-gammaLung DiseasesMaleAntibodies, BacterialInterferon-gamma

Identifiers

PMID25111142
PMCPMC4128648
OpenAlexW2012232318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.