Evidence map›Paper›PMID 25111060›Full record

ArticleJournal of physical activity & health2015

Recreational Exercise Before and During Pregnancy in Relation to Plasma C-Reactive Protein Concentrations in Pregnant Women.

Yan Wang, Lea A Cupul-Uicab, Walter J Rogan, Merete Eggesbo, Gregory Travlos, Ralph Wilson, Matthew P Longnecker

Abstract read
In one paragraph

Article in Journal of physical activity & health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Exercise benefits yourself and your offspring: a mini-review.Frontiers in cell and developmental biology · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Exercise and its role in gestational diabetes mellitus.Chronic diseases and translational medicine · 2016
    Review
  15. Maternal inflammation during late pregnancy is lower in physically active compared with inactive obese women.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Observational
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan WangDept of Health and Human Services, National Institute of Environmental Health Sciences, National Institute of Health, Durham, NC.
Lea A Cupul-Uicab
Walter J Rogan
Merete Eggesbo
Gregory Travlos
Ralph Wilson
Matthew P Longnecker

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
The Norwegian Mother And Child Study: Environmental Specimen CollectionZIAES044008 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2018
$4.3M
Estrogenicity Of Soy FormulaZIAES044006 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ROGAN, WALTER · 2009 to 2015
$2.7M
Intramural NIH HHS ZIA ES044008NIEHS NIH HHS N01 ES075558NIEHS NIH HHS N01-ES75558NINDS NIH HHS 1UO1-NS047537-01NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

backgroundPregnant women who are physically active have a lower risk of preeclampsia and gestational diabetes than women who are less active. One possible mechanism is a reduction in low-grade inflammation, as measured by plasma concentrations of C-reactive protein (CRP). The association between exercise and CRP in pregnant women, however, has not been adequately investigated.

methodsA total of 537 pregnant women, enrolled around the 17th week of gestation in the Norwegian Mother and Child Cohort Study in 2003 to 2004, were studied. Self-reported recreational exercise was recalled for both 3 months before pregnancy and early pregnancy. The total energy expenditure from recreational exercise (total recreational exercise, metabolic equivalent of task [MET]-hr/week) was estimated, and low-, moderate- and vigorous-intensity exercise was defined. Plasma CRP concentrations were measured during pregnancy.

resultsIn adjusted linear regression models, mean CRP concentration was 1.0% lower [95% CI = -1.9% to 0.2%] with each 1 MET-hr/week of total recreational exercise before pregnancy. In addition, vigorous-intensity exercise before pregnancy was more strongly related to a reduction in CRP levels than low- or moderate-intensity exercise. However, we observed no association between recreational exercise during pregnancy and plasma CRP levels.

conclusionsRecreational exercise before pregnancy, especially vigorous exercise, may reduce the risk of maternal inflammation during pregnancy.

Indexed as

AdultChildCohort StudiesC-Reactive ProteinExerciseFemaleHumansPregnancyC-Reactive Protein

Identifiers

PMID25111060
PMCPMC4320677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.