ArticlePloS one2014
Genotoxicity of tri- and hexavalent chromium compounds in vivo and their modes of action on DNA damage in vitro.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Remediating effects of coral fossils on hematobiochemical, histo accumulation and organ histomorphological changes in Chromium intoxicated broilers.Poultry science · 2026Article
- Health Risk Assessment and Bioactive Potential in Wild Food Plants from Deosai: A High-Altitude Ecosystem in Northern Pakistan.Biological trace element research · 2026Article
- Histological and Inflammatory Changes in Thyroid Glands and Early Growth Outcomes in Offspring of Rats Exposed to Ambient Air Pollution near a Petrochemical Complex: A Preliminary Study.Life (Basel, Switzerland) · 2026Article
- Review
- Comparative chromium adsorptive capacity of different low-cost materials using fixed bed column.Scientific reports · 2025Article
- Article
- Metal Ion Signaling in Biomedicine.Chemical reviews · 2025Review
- Article
- Human and ecological risk assessments of potentially toxic elements in sediments around a pharmaceutical industry.Heliyon · 2024Article
- Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk.International journal of molecular sciences · 2024Review
- Removal of Chromium (III) and Reduction in Toxicity in a Primary Tannery Effluent Using Two Floating Macrophytes.Toxics · 2024Article
- Review
- Spatial distribution, sources and health risk assessment of heavy metals in topsoil around oil and natural gas drilling sites, Andhra Pradesh, India.Scientific reports · 2023Article
- Potential Toxic elements in shellfish from three rivers in Niger Delta, Nigeria: bioaccumulation, dietary intake, and human health risk assessment.Environmental analysis, health and toxicology · 2023Article
- Heavy metal resistance in the Yanomami and Tunapuco microbiome.Memorias do Instituto Oswaldo Cruz · 2023Article
- Article
- Article
- RETRACTED: Neuroprotective effect of sodium alginate against chromium-induced brain damage in rats.PloS one · 2022Article
- Integrated review of the nexus between toxic elements in the environment and human health.AIMS public health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromium occurs mostly in tri- and hexavalent states in the environment. Hexavalent chromium [Cr(VI)] compounds are extensively used in diverse industries, and trivalent chromium [Cr(III)] salts are used as micronutrients and dietary supplements. In the present work, we report that they both induce genetic mutations in yeast cells. They both also cause DNA damage in both yeast and Jurkat cells and the effect of Cr(III) is greater than that of Cr(VI). We further show that Cr(III) and Cr(VI) cause DNA damage through different mechanisms. Cr(VI) intercalates DNA and Cr(III) interferes base pair stacking. Based on our results, we conclude that Cr(III) can directly cause genotoxicity in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.