Evidence map›Paper›PMID 25110920›Full record

ArticleJAMA neurology2014

Is apolipoprotein e required for cognitive function in humans?: implications for Alzheimer drug development.

Courtney Lane-Donovan, Joachim Herz

Abstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Courtney Lane-DonovanDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas2Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas.
Joachim HerzDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas2Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas3Department of Neuroscience, University of Texas Southw.

Funding

Metabolism of the VLDL receptor and ApoE receptor 2R37HL063762 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2010 to 2019
$4.0M
METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2R01HL063762 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2000 to 2009
$3.1M
The Role of Reelin in Adult Neuronal Function and Alzheimer's DiseaseF30AG047799 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LANE-DONOVAN, COURTNEY E · 2014 to 2015
$58k
NHLBI NIH HHS HL63762NHLBI NIH HHS R01 HL063762NHLBI NIH HHS R37 HL063762NIA NIH HHS F30 AG047799PHS HHS A108400
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Apolipoproteins EATP-Binding Cassette, Sub-Family C ProteinsHumansHyperlipoproteinemia Type IIILipaseMaleMultidrug Resistance-Associated Protein 2Apolipoproteins EATP-Binding Cassette, Sub-Family C ProteinsLipaseLIPC protein, humanMultidrug Resistance-Associated Protein 2

Identifiers

PMID25110920
PMCPMC4354854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.