Evidence map›Paper›PMID 25110625›Full record

ArticleCurrent ophthalmology reports2014

The Immune System and AMD.

Paul A Frederick, Mark E Kleinman

Abstract read
In one paragraph

Article in Current ophthalmology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Observational
  5. Review
  6. Review
  7. Protein Microarrays for Ocular Diseases.Methods in molecular biology (Clifton, N.J.) · 2021
    Review
  8. Evaluation of serum interferons in patients with age-related macular degeneration.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paul A Frederick
Mark E Kleinman

Funding

Endothelial Cell Dysregulation in Neovascular AMDK08EY021757 · NEI · UNIVERSITY OF KENTUCKY · PI KLEINMAN, MARK E · 2011 to 2015
$1.6M
NEI NIH HHS K08 EY021757
6 · The paper itself

Abstract

Age related macular degeneration (AMD) is a complex, multifactorial disease that has yet to be completely understood. Significant efforts in the basic and clinical sciences have unveiled numerous areas which appear to be critical in the pathogenesis of this disease. The alternative complement pathway, immune cell activation, and autoimmunity are all emerging as important themes to the suspected immunologic origins of this disease. Advancement toward a complete understanding of these processes is important in development of new techniques for disease monitoring and treatment.

Indexed as

AMDanti-retinal autoantibodieschemokine receptorschoroidal neovascularizationcomplement pathwaysdrusenimmunologymacrophagetoll-like receptors

Identifiers

PMID25110625
PMCPMC4122127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.