ArticleF1000Research2013
Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus.
Article in F1000Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Development of subdomains in the medial pallium ofFrontiers in neuroanatomy · 2022Article
- Article
- Antiepileptogenic Effect of Retinoic Acid.Current neuropharmacology · 2021Article
- Neurological disorder-associated genetic variants in individuals with psychogenic nonepileptic seizures.Scientific reports · 2020Article
- Generation and characterization of Lhx9-GFPCreER(T2) knock-in mouse line.Genesis (New York, N.Y. : 2000) · 2014Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
The LIM-homeodomain (LIM-HD) family of transcription factors is well known for its functions during several developmental processes including cell fate specification, cell migration and axon guidance, and its members play fundamental roles in hippocampal development. The hippocampus is a structure that displays striking activity dependent plasticity. We examined whether LIM-HD genes and their co-factors are regulated during kainic acid induced seizure in the adult rat hippocampus as well as in early postnatal rats, when the hippocampal circuitry is not fully developed. We report a distinct and field-specific regulation of LIM-HD genes Lhx1, Lhx2, and Lhx9, LIM-only gene Lmo4, and cofactor Clim1a in the adult hippocampus after seizure induction. In contrast none of these genes displayed altered levels upon induction of seizure in postnatal animals. Our results provide evidence of temporal and spatial seizure mediated regulation of LIM-HD family members and suggest that LIM-HD gene function may be involved in activity dependent plasticity in the adult hippocampus.
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Registered trials
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