ArticleNutrition research and practice2014
Effect of Hominis Placenta on cutaneous wound healing in normal and diabetic mice.
Article in Nutrition research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Effectiveness and safety of combining pharmacopuncture therapy and acupotomy for treating patients with degenerative lumbar spinal stenosis: A pragmatic, assessor-blinded, randomized, controlled trial.Integrative medicine research · 2026Article
- Pharmacopuncture Therapy as an Adjunctive Treatment for Patients with Lumbar Spinal Stenosis: A Pragmatic Randomized Controlled Pilot Trial.Journal of pain research · 2024Article
- 3D-printed placental-derived bioinks for skin tissue regeneration with improved angiogenesis and wound healing properties.Materials today. Bio · 2023Article
- Randomized, single-blind, placebo-controlled trial onIntegrative medicine research · 2022Article
- Review
- Effects of novel Fufang Biejia Ruangan Tablets with sheep placenta as substitute forChinese herbal medicines · 2022Article
- Highly elastic 3D-printed gelatin/HA/placental-extract scaffolds for bone tissue engineering.Theranostics · 2022Article
- Therapeutic Effect of Murine Bone Marrow-Derived Mesenchymal Stromal/Stem Cells and Human Placental Extract on Testicular Toxicity Resulting from Doxorubicin in Rats.BioMed research international · 2021Article
- Article
- Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages.International journal of molecular medicine · 2019Article
- Anti‑apoptotic effects of human placental hydrolysate against hepatocyte toxicity in vivo and in vitro.International journal of molecular medicine · 2018Article
- Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects.Stem cells international · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe number of diabetic patients has recently shown a rapid increase, and delayed wound healing is a major clinical complication in diabetes. In this study, the wound healing effect of Hominis placenta (HP) treatment was investigated in normal and streptozotocin-induced diabetic mice. MATERIALS/
methodsFour full thickness wounds were created using a 4 mm biopsy punch on the dorsum. HP was injected subcutaneously at the middle region of the upper and lower wounds. Wounds were digitally photographed and wound size was measured every other day until the 14th day. Wound closure rate was analyzed using CANVAS 7SE software. Wound tissues were collected on days 2, 6, and 14 after wounding for H/E, immunohistochemistry for FGF2, and Masson's trichrome staining for collagen study.
resultsSignificantly faster wound closure rates were observed in the HP treated group than in normal and diabetes control mice on days 6 and 8. Treatment with HP resulted in reduced localization of inflammatory cells in wounded skin at day 6 in normal mice and at day 14 in diabetic mice (P < 0.01). Expression of fibroblast growth factor (FGF) 2 showed a significant increase in the HP treated group on day 14 in both normal (P < 0.01) and diabetic mice (P < 0.05). In addition, HP treated groups showed a thicker collagen layer than no treatment groups, which was remarkable on the last day, day 14, in both normal and diabetic mice.
conclusionsTaken together, HP treatment has a beneficial effect on acceleration of cutaneous wound healing via regulation of the entire wound healing process, including inflammation, proliferation, and remodeling.
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