Evidence map›Paper›PMID 25110463›Full record

ArticleBMC anesthesiology2014

Nasal high-flow oxygen therapy in patients with hypoxic respiratory failure: effect on functional and subjective respiratory parameters compared to conventional oxygen therapy and non-invasive ventilation (NIV).

Norbert Schwabbauer, Björn Berg, Gunnar Blumenstock, Michael Haap, Jürgen Hetzel, Reimer Riessen

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 70 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 13 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03460119 completednot on this mapstarted 2015, after this paper: background citation

Use of High-Flow Nasal Cannula for Acute Respiratory Failure in the Emergency Department

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2015 to 2017Enrolled43ConditionsAcute Respiratory FailureArmsHigh Flow Nasal Cannula Oxygen
NCT04368325 completednot on this mapstarted 2015, after this paper: background citation

A Correlation of Low Serum Creatinine Levels and Respiratory Function in the Mechanically Ventilated Patients in the Intensive Care Unit

Typeobservational_patient_registrySponsorOsijek University HospitalRan2015 to 2017Enrolled107ConditionsIntensive Care Unit, Respiratory Insufficiency, Muscle WeaknessArmsSerum creatinine levels
NCT04683952 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Efficacy of Exercise Training With Humified High Flow Nasal Cannula, in Patients With Chronic Obstructive Pulmonary Disease Already in Nocturnal Non-Invasive Ventilation

TypeinterventionalSponsorFondazione Don Carlo Gnocchi ETSRan2020 to 2022Enrolled30ConditionsChronic Obstructive Pulmonary DiseaseArmsExercise training with Humified High Flow Nasal Cannula, Exercise training - Control Group
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 13 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Norbert SchwabbauerDepartment of Internal Medicine, Medical Intensive Care Unit, University of Tübingen, Otfried-Müller-Str, 10, Tübingen 72076, Germany.
Björn BergDepartment of Internal Medicine, Medical Intensive Care Unit, University of Tübingen, Otfried-Müller-Str, 10, Tübingen 72076, Germany.
Gunnar BlumenstockDepartment of Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany.
Michael HaapDepartment of Internal Medicine, Medical Intensive Care Unit, University of Tübingen, Otfried-Müller-Str, 10, Tübingen 72076, Germany.
Jürgen HetzelDepartment of Internal Medicine, Division of Pulmonary Medicine, University of Tübingen, Tübingen, Germany.
Reimer RiessenDepartment of Internal Medicine, Medical Intensive Care Unit, University of Tübingen, Otfried-Müller-Str, 10, Tübingen 72076, Germany.
University of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAim of the study was to compare the short-term effects of oxygen therapy via a high-flow nasal cannula (HFNC) on functional and subjective respiratory parameters in patients with acute hypoxic respiratory failure in comparison to non-invasive ventilation (NIV) and standard treatment via a Venturi mask.

methodsFourteen patients with acute hypoxic respiratory failure were treated with HFNC (FiO2 0.6, gas flow 55 l/min), NIV (FiO2 0.6, PEEP 5 cm H2O Hg, tidal volume 6-8 ml/kg ideal body weight,) and Venturi mask (FiO2 0.6, oxygen flow 15 l/min,) in a randomized order for 30 min each. Data collection included objective respiratory and circulatory parameters as well as a subjective rating of dyspnea and discomfort by the patients on a 10-point scale. In a final interview, all three methods were comparatively evaluated by each patient using a scale from 1 (=very good) to 6 (=failed) and the patients were asked to choose one method for further treatment.

resultsPaO2 was highest under NIV (129 ± 38 mmHg) compared to HFNC (101 ± 34 mmHg, p <0.01 vs. NIV) and VM (85 ± 21 mmHg, p <0.001 vs. NIV, p <0.01 vs. HFNC, ANOVA). All other functional parameters showed no relevant differences. In contrast, dyspnea was significantly better using a HFNC (2.9 ± 2.1, 10-point Borg scale) compared to NIV (5.0 ± 3.3, p <0.05), whereas dyspnea rating under HFNC and VM (3.3 ± 2.3) was not significantly different. A similar pattern was found when patients rated their overall discomfort on the 10 point scale: HFNC 2.7 ± 1.8, VM 3.1 ± 2.8 (ns vs. HFNC), NIV 5.4 ± 3.1 (p <0.05 vs. HFNC). In the final evaluation patients gave the best ratings to HFNC 2.3 ± 1.4, followed by VM 3.2 ± 1.7 (ns vs. HFNC) and NIV 4.5 ± 1.7 (p <0.01 vs. HFNC and p <0.05 vs. VM). For further treatment 10 patients chose HFNC, three VM and one NIV.

conclusionsIn hypoxic respiratory failure HFNC offers a good balance between oxygenation and comfort compared to NIV and Venturi mask and seems to be well tolerated by patients.

trial registrationGERMAN CLINICAL TRIALS REGISTER: DRKS00005132.

Indexed as

AdolescentAdultAgedAged, 80 and overDyspneaFemaleHemodynamicsHumansHypoxiaMaleMasksMiddle AgedNoninvasive VentilationOxygen ConsumptionOxygen Inhalation TherapyRespiratory Function TestsHigh-flow nasal cannulaNon-invasive ventilationOxygenRespiratory failureVenturi mask

Identifiers

PMID25110463
PMCPMC4126617
OpenAlexW2131662900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.