Evidence map›Paper›PMID 25110443›Full record

Trial reportWorld journal of gastroenterology2014

Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?

Zoltán Döbrönte, Zoltán Szepes, Ferenc Izbéki, Judit Gervain, László Lakatos, Gyula Pécsi, Miklós Ihász, Lilla Lakner, Erzsébet Toldy, László Czakó

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 10 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 10 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. NSAIDs do not reduce severity among post-ERCP pancreatitis patients.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2024
    Pooled it
  5. Nonsteroidal Anti-inflammatory Drugs for Endoscopic Retrograde Cholangiopancreatography Postoperative Pancreatitis Prevention: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zoltán DöbrönteZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
Zoltán SzepesZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
Ferenc IzbékiZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
Judit GervainZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
László LakatosZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
Gyula PécsiZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
Miklós IhászZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
Lilla LaknerZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
Erzsébet ToldyZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
László CzakóZoltán Döbrönte, Miklós Ihász, Lilla Lakner, Department of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, H-9700 Szombathely, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasaemia in a multicentre study.

methodsA prospective, randomised, placebo-controlled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin, or an inert placebo, 10-15 min before ERCP. Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters, and computed tomography/magnetic resonance imaging findings if required.

resultsTwenty-one patients were excluded because of incompleteness of their data or because of protocol violation. The results of 665 investigations were evaluated: 347 in the indomethacin group and 318 in the placebo group. The distributions of the risk factors in the two groups did not differ significantly. Pancreatitis developed in 42 patients (6.3%): it was mild in 34 (5.1%) and severe in eight (1.2%) cases. Hyperamylaesemia occurred in 160 patients (24.1%). There was no significant difference between the indomethacin and placebo groups in the incidence of either post-ERCP pancreatitis (5.8% vs 6.9%) or hyperamylasaemia (23.3% vs 24.8%). Similarly, subgroup analysis did not reveal any significant differences between the two groups.

conclusion100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis.

Indexed as

Administration, RectalAgedAged, 80 and overCholangiopancreatography, Endoscopic RetrogradeCyclooxygenase InhibitorsFemaleHumansHungaryHyperamylasemiaIncidenceIndomethacinMagnetic Resonance ImagingMaleMiddle AgedPancreatitisProspective StudiesCyclooxygenase InhibitorsIndomethacinSuppositoriesEndoscopic retrograde cholangiopancreatographyHyperamylasaemiaIndomethacinNon-steroidal anti-inflammatory drugsPost-endoscopic retrograde cholangiopancreatography pancreatitis

Identifiers

PMID25110443
PMCPMC4123345
OpenAlexW2343403036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.