Evidence map›Paper›PMID 25110429›Full record

ReviewWorld journal of gastroenterology2014

Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas.

Marina Paini, Stefano Crippa, Stefano Partelli, Filippo Scopelliti, Domenico Tamburrino, Andrea Baldoni, Massimo Falconi

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Clinical and Molecular Attributes and Evaluation of Pancreatic Cystic Neoplasm.Biochimica et biophysica acta. Reviews on cancer · 2023
    Review
  4. Review
  5. Article
  6. Molecular Diagnosis of Cystic Neoplasms of the Pancreas: a Review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Review
  7. Review
  8. Review
  9. Review
  10. The genetic classification of pancreatic neoplasia.Journal of gastroenterology · 2015
    Review
  11. Modern aspects of the management of pancreatic intraductal papillary mucinous neoplasms: a narrative review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marina PainiMarina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), Italy.
Stefano CrippaMarina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), Italy.
Stefano PartelliMarina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), Italy.
Filippo ScopellitiMarina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), Italy.
Domenico TamburrinoMarina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), Italy.
Andrea BaldoniMarina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), Italy.
Massimo FalconiMarina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), Italy.
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the first description of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in the eighties, their identification has dramatically increased in the last decades, hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic diseases. However, the heterogeneity of IPMNs and their malignant potential make difficult the management of these lesions. The objective of this review is to identify the molecular characteristics of IPMNs in order to recognize potential markers for the discrimination of more aggressive IPMNs requiring surgical resection from benign IPMNs that could be observed. We briefly summarize recent research findings on the genetics and epigenetics of intraductal papillary mucinous neoplasms, identifying some genes, molecular mechanisms and cellular signaling pathways correlated to the pathogenesis of IPMNs and their progression to malignancy. The knowledge of molecular biology of IPMNs has impressively developed over the last few years. A great amount of genes functioning as oncogenes or tumor suppressor genes have been identified, in pancreatic juice or in blood or in the samples from the pancreatic resections, but further researches are required to use these informations for clinical intent, in order to better define the natural history of these diseases and to improve their management.

Indexed as

Biomarkers, TumorCarcinoma, Pancreatic DuctalCarcinoma, PapillaryDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGenetic TestingHumansNeoplasms, Cystic, Mucinous, and SerousPancreatic NeoplasmsPhenotypePredictive Value of TestsSignal TransductionBiomarkers, TumorDysplasiaIntraductal papillary mucinous neoplasmMalignant transformationMolecular pathologyOncogenePancreasPancreatic cancerTumor suppressor gene

Identifiers

PMID25110429
PMCPMC4123331
OpenAlexW1968771230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.