ReviewWorld journal of gastroenterology2014
Spontaneous free perforation of the small intestine in adults.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- A systemic review and metaanalysis of postoperative outcomes in urgent and elective bowel resection in patients with Crohn's disease.International journal of colorectal disease · 2021Pooled it
- Prevalence, anatomic-pathologic findings, and associated factors of nontraumatic ileal perforations among patients with gut perforation: a multicenter cross-sectional study.BMC gastroenterology · 2026Article
- Ileal perforation as the initial presentation of Crohn's disease in a 20-year-old female: a case report.Journal of surgical case reports · 2026Article
- Risk Stratification Tools and Scoring Systems in Perforated Viscus: A Systematic Review.Cureus · 2025Review
- Strangulated Inguinal Hernia With Intraperitoneal Proximal Bowel Perforation: An Unusual Presentation.Cureus · 2025Article
- Sequential gastric and ileal perforations, a rare presentation in a man with sickle cell anemia: A case report.The Journal of international medical research · 2025Article
- Spontaneous multiple small bowel perforations due to ischemic enteritis: a case report.BMC geriatrics · 2025Article
- Perforated small bowel lymphoma: a rare presentation of Crohn's disease.Journal of surgical case reports · 2024Article
- Classification und Treatment Algorithm of Small Bowel Perforations Based on a Ten-Year Retrospective Analysis.Journal of clinical medicine · 2022Article
- Nontraumatic perforation of the small intestine caused by true primary enteroliths associated with radiation enteritis: a case report.Surgical case reports · 2021Article
- Spontaneous small bowel perforation secondary toWorld journal of clinical cases · 2021Article
- Article
- Cessation of methotrexate and a small intestinal resection provide a good clinical course for a patient with a jejunum perforation induced by a methotrexate-associated lymphoproliferative disorder: a case report.World journal of surgical oncology · 2021Article
- Article
- Endoscopic management of perforations, leaks and fistulas.Translational gastroenterology and hepatology · 2018Review
- Multiple spontaneous small bowel perforations due to clozapine-Case report.International journal of surgery case reports · 2018Article
- Intestinal perforation after surgical treatment for incisional hernia: iatrogenic or idiopathic?Case reports in plastic surgery & hand surgery · 2018Article
- A rare presentation of an acute abdomen: an ileal diverticular perforation.BMC research notes · 2017Article
- A case report of small bowel perforation secondary to cytomegalovirus related immune reconstitution inflammatory syndrome in an AIDS patient.Annals of medicine and surgery (2012) · 2017Article
- Spontaneous seromuscular laceration of the sigmoid colon: a case report.Clinical case reports · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous free perforation of the small intestine is uncommon, especially if there is no prior history of visceral trauma. However, free, even recurrent, perforation may complicate a defined and established clinical disorder, such as Crohn's disease. In addition, free perforation may be the initial clinical presentation of an occult intestinal disorder, such as a lymphoma complicating celiac disease, causing diffuse peritonitis and an acute abdomen. Initial diagnosis of the precise cause may be difficult, but now has been aided by computerized tomographic imaging. The site of perforation may be helpful in defining a cause (e.g., ileal perforation in Crohn's disease, jejunal perforation in celiac disease, complicated by lymphoma or collagenous sprue). Urgent surgical intervention, however, is usually required for precise diagnosis and treatment. During evaluation, an expanding list of other possible causes should be considered, even after surgery, as subsequent management may be affected. Free perforation may not only complicate an established intestinal disorder, but also a new acute process (e.g., caused by different infectious agents) or a longstanding and unrecognized disorder (e.g., congenital, metabolic and vascular causes). Moreover, new endoscopic therapeutic and medical therapies, including use of emerging novel biological agents, have been complicated by intestinal perforation. Recent studies also support the hypothesis that perforation of the small intestine may be genetically-based with different mutations causing altered connective tissue structure, synthesis and repair.
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