Evidence map›Paper›PMID 25110406›Full record

SynthesisWorld journal of gastroenterology2014

Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis.

Imerio Angriman, Marco Scarpa, Ignazio Castagliuolo

2 registry-linked trialsOpen access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03136419 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Microbiota and Immune microEnvironment in Pouchitis: Randomized Controlled Trial Oral Administration of Lactobacillus Casei DG After Ileostomy Closure in Ileal Pouch Mucosa

TypeinterventionalSponsorUniversity of PadovaRan2016 to 2019Enrolled32ConditionsPouchitis, Ulcerative Colitis, Ileal PouchArmsLactobacillus casei DG, Placebo
NCT03538366 nacompletednot on this mapstarted 2018, after this paper: background citation

Fecal Microbiota Transplantation for the Treatment of Chronic Pouchitis

TypeinterventionalSponsorAalborg University HospitalRan2018 to 2019Enrolled10ConditionsUlcerative Colitis, PouchitisArmsDonor FMT
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Imerio AngrimanImerio Angriman, Department of Surgery, Gastroenterology and Oncology, University of Padova, 35128 Padova, Italy.
Marco ScarpaImerio Angriman, Department of Surgery, Gastroenterology and Oncology, University of Padova, 35128 Padova, Italy.
Ignazio CastagliuoloImerio Angriman, Department of Surgery, Gastroenterology and Oncology, University of Padova, 35128 Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has become the surgical treatment of choice for many patients with medically refractory ulcerative colitis (UC) and familial adenomatous polyposis (FAP). UC patients with IPAA (UC-IPAA) are, nevertheless, susceptible to inflammatory and noninflammatory sequelae such as pouchitis, which is only rarely noted in FAP patients with IPAA. Pouchitis is the most frequent long-term complication of UC-IPAA patients, with a cumulative prevalence of up to 50%. Although the aetiology of pouchitis remains unclear, accumulating evidence suggests that a dysbiosis of the pouch microbiota and an abnormal mucosal immune response are implicated in its pathogenesis. Studies using culture and molecular techniques have detected a dysbiosis of the pouch microbiota in patients with pouchitis. Risk factors, genetic associations, and serological markers suggest that interactions between the host immune response and the pouch microbiota underlie the aetiology of this idiopathic inflammatory condition. This systematic review focuses on the dysbiosis of the microbiota that inhabit the pouch in UC and FAP patients and its interaction with the mucosal immune system. A meta-analysis was not attempted due to the highly heterogeneous microbiota composition and the different detection methods used by the various studies. Although no specific bacterial species, genus, or family has as yet been identified as pathogenic, there is evidence that a dysbiosis characterized by decreased gut microbiota diversity in UC-IPAA patients may, in genetically predisposed subjects, lead to aberrant mucosal immune regulation triggering an inflammatory process.

Indexed as

BacteriaColitis, UlcerativeDysbiosisHost-Pathogen InteractionsHumansImmunity, MucosalInflammation MediatorsPouchitisProctocolectomy, RestorativeRisk FactorsInflammation MediatorsBacteriaCrohn’s diseaseIleal-pouch-anal anastomosisInflammation of the ileal pouchInflammatory bowel diseaseMicrobiomeMicrobiotaPouchitisUlcerative colitis

Identifiers

PMID25110406
PMCPMC4123357
OpenAlexW2046766999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.