Evidence map›Paper›PMID 25110284›Full record

ArticleActa biomaterialia2014

Electrospun biodegradable elastic polyurethane scaffolds with dipyridamole release for small diameter vascular grafts.

Primana Punnakitikashem, Danh Truong, Jyothi U Menon, Kytai T Nguyen, Yi Hong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 128 citations in OpenAlex.

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  15. Electrospun nanofiber scaffold for vascular tissue engineering.Materials science & engineering. C, Materials for biological applications · 2021
    Review
  16. Development of drug loaded cardiovascular prosthesis for thrombosis prevention using 3D printing.Materials science & engineering. C, Materials for biological applications · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Primana PunnakitikashemDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA; Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Danh TruongDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA; Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jyothi U MenonDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA; Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kytai T NguyenDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA; Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yi HongDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA; Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: yihong@uta.edu.
The University of Texas at Arlington · US

Funding

Novel Engineered Particle Platform for Endothelium RegenerationR01HL118498 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NGUYEN, KYTAI TRUONG, YANG, JIAN · 2014 to 2017
$1.5M
NHLBI NIH HHS HL118498NHLBI NIH HHS R01 HL118498
6 · The paper itself

Abstract

Acellular biodegradable small diameter vascular grafts (SDVGs) require antithrombosis, intimal hyperplasia inhibition and rapid endothelialization to improve the graft patency. However, current antithrombosis and antiproliferation approaches often conflict with endothelial cell layer formation on SDVGs. To address this limitation, biodegradable elastic polyurethane urea (BPU) and the drug dipyridamole (DPA) were mixed and then electrospun into a biodegradable fibrous scaffold. The BPU would provide the appropriate mechanical support, while the DPA in the scaffold would offer biofunctions as required above. We found that the resulting scaffolds had tensile strengths and strains comparable with human coronary artery. The DPA in the scaffolds was continuously released up to 91 days in phosphate buffer solution at 37 °C, with a low burst release within the first 3 days. Compared to BPU alone, improved non-thrombogenicity of the DPA-loaded BPU scaffolds was evidenced with extended human blood clotting time, lower TAT complex concentration, lower hemolysis and reduced human platelet deposition. The scaffolds with a higher DPA content (5 and 10%) inhibited proliferation of human aortic smooth muscle cell significantly. Furthermore, the DPA-loaded scaffolds had no adverse effect on human aortic endothelial cell growth, yet it improved their proliferation. The attractive mechanical properties and biofunctions of the DPA-loaded BPU scaffold indicate its potential as an acellular biodegradable SDVG for vascular replacement.

Indexed as

Blood Vessel ProsthesisElasticityAortaBiocompatible MaterialsBlood PlateletsCell ProliferationCell ShapeDipyridamoleHumansMyocytes, Smooth MusclePolyurethanesStaining and LabelingTime FactorsTissue ScaffoldsBiocompatible MaterialsDipyridamolepolyetherurethane ureaPolyurethanesControlled releaseDipyridamoleElectrospinningPolyurethaneSmall diameter vascular graft

Identifiers

PMID25110284
PMCPMC4234112
OpenAlexW2054294448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.