Evidence map›Paper›PMID 25110250›Full record

ReviewGastroenterology clinics of North America2014

Immunology of inflammatory bowel disease and molecular targets for biologics.

Maneesh Dave, Konstantinos A Papadakis, William A Faubion

Abstract readReview
In one paragraph

Review in Gastroenterology clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Gastrointestinal complications after kidney transplantation.World journal of gastroenterology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maneesh DaveDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Konstantinos A PapadakisDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
William A FaubionDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: faubion.william@mayo.edu.

Funding

KLF10 regulates colitis through mediating TGFb induction of FOXP3 in Treg cells.R01AI089714 · NIAID · MAYO CLINIC ROCHESTER · PI FAUBION, WILLIAM A · 2011 to 2025
$6.3M
NIAID NIH HHS R01 AI089714
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is an immune-mediated disease and involves a complex interplay of host genetics and environmental influences. Recent advances in the field, including data from genome-wide association studies and microbiome analysis, have started to unravel the complex interaction between host genetics and environmental influences in the pathogenesis of IBD. A drawback of current clinical trials is inadequate or lack of immune phenotyping of patients. However, recent advances in high-throughput technologies provide an opportunity to monitor the dynamic and complex immune system, which may to lead to a more personalized treatment approach in IBD.

Indexed as

Immunity, InnateImmunity, MucosalAnimalsDendritic CellsHumansInflammatory Bowel DiseasesIntestinesMacrophagesMicrobiotaT-LymphocytesAdaptive immunityBiologicsIBDImmunologyInnate immunity

Identifiers

PMID25110250
PMCPMC4480636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.