ReviewBiochemical Society transactions2014
Deregulated coenzyme A, loss of metabolic flexibility and diabetes.
Review in Biochemical Society transactions, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Discovery of Sulfonamide Pantothenate Kinase Activators and Elucidation of the Role of Isoform Selectivity in Cellular Pantothenate Kinase Activation.Journal of medicinal chemistry · 2026Article
- Biomarker potential of vanin-1-derived pantothenic acid in diabetes and its associated cardiovascular complications.Scientific reports · 2025Article
- Multi-omics signature of healthy versus unhealthy lifestyles reveals associations with diseases.Human genomics · 2025Article
- MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation.Nucleic acids research · 2024Article
- Manipulation of pantothenate kinase in Anopheles stephensi suppresses pantothenate levels with minimal impacts on mosquito fitness.Insect biochemistry and molecular biology · 2022Article
- Generation and Validation of an Anti-Human PANK3 Mouse Monoclonal Antibody.Biomolecules · 2022Article
- The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity.ACS chemical biology · 2021Article
- Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy.Chinese medicine · 2021Article
- Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan.Antioxidants (Basel, Switzerland) · 2021Review
- WIDOCK: a reactive docking protocol for virtual screening of covalent inhibitors.Journal of computer-aided molecular design · 2021Article
- The Pathophysiological Role of CoA.International journal of molecular sciences · 2020Review
- Extensive metabolic remodeling after limiting mitochondrial lipid burden is consistent with an improved metabolic health profile.The Journal of biological chemistry · 2019Article
- Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.Journal of the American Chemical Society · 2019Article
- Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility.Cell reports · 2018Article
- Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.The Journal of biological chemistry · 2018Article
- Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection.Molecules (Basel, Switzerland) · 2017Article
- Acetyl-CoA and the regulation of metabolism: mechanisms and consequences.Current opinion in cell biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
CoA (coenzyme A) is an essential cofactor that is emerging as a global regulator of energy metabolism. Tissue CoA levels are tightly regulated and vary in response to different conditions including nutritional state and diabetes. Recent studies reveal the ability of this cofactor to control the output of key metabolic pathways. CoA regulation is important for the maintenance of metabolic flexibility and glucose homoeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.