ArticleThe EMBO journal1989
The smaller human VH gene families display remarkably little polymorphism.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Grade I, II and III Follicular Lymphomas Express Ig VPathology oncology research : POR · 2020Article
- 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.PloS one · 2012Article
- Age-related accumulation of Ig V(H) gene somatic mutations in peripheral B cells from aged humans.Clinical and experimental immunology · 2003Article
- Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance.The Journal of clinical investigation · 2001Article
- Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.Immunology · 2001Article
- Impact of age on hypermutation of immunoglobulin variable genes in humans.Journal of clinical immunology · 2001Article
- The super-information age of immunoglobulin genetics.The Journal of experimental medicine · 1998Article
- Clonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synovium.Molecular medicine (Cambridge, Mass.) · 1998Article
- Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis.Journal of immunology (Baltimore, Md. : 1950) · 1998Article
- Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.The Journal of experimental medicine · 1998Article
- Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells.Blood · 1997Article
- Memory B lymphocytes migrate to bone marrow in humans.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Sequence analysis of rearranged IgVH genes from microdissected human Peyer's patch marginal zone B cells.Immunology · 1996Article
- Ethnic differences of polymorphism of an immunoglobulin VH3 gene.The Journal of clinical investigation · 1995Article
- Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells.The Journal of experimental medicine · 1995Article
- Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.Molecular medicine (Cambridge, Mass.) · 1995Article
- Superantigen properties of a human sialoprotein involved in gut-associated immunity.The Journal of clinical investigation · 1995Article
- Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.The Journal of clinical investigation · 1995Article
- Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice.The Journal of experimental medicine · 1995Article
- The molecular structure of human antibodies specific for the human immunodeficiency virus.Journal of clinical immunology · 1995Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the nucleotide sequence of 30 distinct human VH gene segments from the VHIV, VHV and VHVI gene families. When these sequences were compared to previously published sequences from these smaller human VH families a surprisingly low level of polymorphism was noted. Two VHIV gene segments from unrelated individuals were identical to two previously published VHIV sequences. Five VHV sequences were identical and seven VHVI gene segments were identical. Where differences were found between the sequences, allele specific oligonucleotide probes were used to verify the germline nature of the change and to test for segregation in several large kindreds. These data provide evidence that at least some human VH gene segments are remarkably stable.
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