ArticleNeurobiology of aging2015
Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).British journal of pharmacology · 2017Trial
- DSOK-0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity-Based Anorexia Model.The International journal of eating disorders · 2026Article
- The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- Contribution of local regeneration of glucocorticoids to tissue steroid pools.The Journal of endocrinology · 2023Article
- 11β-HSD as a New Target in Pharmacotherapy of Metabolic Diseases.International journal of molecular sciences · 2022Review
- Inhibition of glucocorticoid synthesis alleviates cognitive impairment in high-fat diet-induced obese mice.Comprehensive psychoneuroendocrinology · 2022Article
- Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1.The Journal of clinical investigation · 2021Article
- Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Cognitive performance in idiopathic intracranial hypertension and relevance of intracranial pressure.Brain communications · 2021Article
- Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota.Scientific reports · 2020Article
- 11β-HSD1 Inhibition Rescues SAMP8 Cognitive Impairment Induced by Metabolic Stress.Molecular neurobiology · 2020Article
- Is AD a Stress-Related Disorder? Focus on the HPA Axis and Its Promising Therapeutic Targets.Frontiers in aging neuroscience · 2019Article
- 11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.Brain, behavior, and immunity · 2018Article
- Midlife stress alters memory and mood-related behaviors in old age: Role of locally activated glucocorticoids.Psychoneuroendocrinology · 2018Article
- Exploring N-acyl-4-azatetracyclo[5.3.2.0Molecules (Basel, Switzerland) · 2018Article
- Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice.Biochemical pharmacology · 2018Article
- A decline in female baboon hypothalamo-pituitary-adrenal axis activity anticipates aging.Aging · 2017Article
- Diabetes and Insulin Injection Modalities: Effects on Hepatic and Hippocampal Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Juvenile Diabetic Male Rats.Frontiers in endocrinology · 2017Article
- Microglia Priming with Aging and Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice.Journal of neuroendocrinology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
11Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) locally amplifies active glucocorticoids within specific tissues including in brain. In the hippocampus, 11β-HSD1 messenger RNA increases with aging. Here, we report significantly greater increases in intrahippocampal corticosterone (CORT) levels in aged wild-type (WT) mice during the acquisition and retrieval trials in a Y-maze than age-matched 11β-HSD1(-/-) mice, corresponding to impaired and intact spatial memory, respectively. Acute stress applied to young WT mice led to increases in intrahippocampal CORT levels similar to the effects of aging and impaired retrieval of spatial memory. 11β-HSD1(-/-) mice resisted the stress-induced memory impairment. Pharmacologic inhibition of 11β-HSD1 abolished increases in intrahippocampal CORT levels during the Y-maze trials and prevented spatial memory impairments in aged WT mice. These data provide the first in vivo evidence that dynamic increases in hippocampal 11β-HSD1 regenerated CORT levels during learning and retrieval play a key role in age- and stress-associated impairments of spatial memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.