Evidence map›Paper›PMID 25109571›Full record

ArticleTrends in pharmacological sciences2014

In vivo veritas: (+)-Naltrexone's actions define translational importance: A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'.

Linda R Watkins, Xiaohui Wang, Sanam Mustafa, Mark R Hutchinson

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Linda R WatkinsDepartment of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA; Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA. Electronic address: Linda.watkins@colorado.edu.
Xiaohui WangDepartment of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA; Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA; Department of Chemistry and Biochemistry, BioFrontiers, University of Colorado at Boulder, Boulder, CO 80309, USA.
Sanam MustafaDepartment of Chemistry and Biochemistry, BioFrontiers, University of Colorado at Boulder, Boulder, CO 80309, USA; Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia.
Mark R HutchinsonDepartment of Chemistry and Biochemistry, BioFrontiers, University of Colorado at Boulder, Boulder, CO 80309, USA; Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia.
University of Colorado Boulder · USUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug Delivery SystemsAnalgesics, OpioidAnimalsHumansToll-Like Receptor 4Analgesics, OpioidToll-Like Receptor 4analgesiadrug abusenaloxonenaltrexonenon-stereoselectiveToll-like receptor 4

Identifiers

PMID25109571
OpenAlexW2068988505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.