Translational potential of naloxone and naltrexone as TLR4 antagonists.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

1. Fentanyl enhances immune cell response through TLR4/MD-2 complex.Frontiers in pharmacology · 2024
   Article
2. Low-dose naltrexone use for the management of post-acute sequelae of COVID-19.International immunopharmacology · 2023
   Article
3. Interaction of Opioids with TLR4-Mechanisms and Ramifications.Cancers · 2021
   Review
4. Immune treatments for alcohol use disorder: A translational framework.Brain, behavior, and immunity · 2021
   Review
5. Toll-Like Receptor 4 Signaling and Drug Addiction.Frontiers in pharmacology · 2020
   Review
6. Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
   Article
7. Neuroimmune signaling in alcohol use disorder.Pharmacology, biochemistry, and behavior · 2019
   Review
8. The Role of Opioid Receptors in Immune System Function.Frontiers in immunology · 2019
   Review
9. Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats.Psychopharmacology · 2018
   Article
10. Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
11. Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors.Progress in neuro-psychopharmacology & biological psychiatry · 2017
    Review
12. Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.Scientific reports · 2017
    Article
13. Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Article
14. Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.Journal of medicinal chemistry · 2015
    Article
15. International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.Pharmacological reviews · 2015
    Review

Corrections and comments

• Commented on by
  In vivo veritas: (+)-Naltrexone's actions define translational importance: A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'.2014
• Comment on
  The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia.2009

Authors and funding

4 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as