Evidence map›Paper›PMID 25109389›Full record

ArticleEchocardiography (Mount Kisco, N.Y.)2015

Effects of frame rate on two-dimensional speckle tracking-derived measurements of myocardial deformation in premature infants.

Aura A Sanchez, Philip T Levy, Timothy J Sekarski, Aaron Hamvas, Mark R Holland, Gautam K Singh

Registry-linked trialAbstract read
In one paragraph

Article in Echocardiography (Mount Kisco, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05235399 (Exploring Right vEntricular Function Applicability in a Prediction mOdel to Identify pReterm infanTs With Early BronchoPulmonary Dysplasia), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05235399 completednot on this mapstarted 2022, after this paper: background citation

Exploring Right vEntricular Function Applicability in a Prediction mOdel to Identify pReterm infanTs With Early BronchoPulmonary Dysplasia (REPORT - BPD Study): a Mixed Methods Observational Cohort Feasibility Study

TypeobservationalSponsorUniversity Hospital Plymouth NHS TrustRan2022 to 2023Enrolled40ConditionsBronchopulmonary Dysplasia, Right Ventricular Dysfunction, In the Perinatal PeriodArmsEcho scans
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2016
    Pooled it
  2. Pooled it
  3. Article
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  6. Article
  7. Vendor independent myocardial strain values in children.Echocardiography (Mount Kisco, N.Y.) · 2023
    Article
  8. Article
  9. Article
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  12. Speckle tracking derived strain in neonates: planes, layers and drift.The international journal of cardiovascular imaging · 2021
    Article
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  14. Article
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  18. Cardiac mechanics in infants with Down syndrome in the early neonatal period.Journal of perinatology : official journal of the California Perinatal Association · 2019
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Aura A SanchezDepartment of Pediatrics, Washington University School of Medicine, Saint Louis Children's Hospital, Saint Louis, Missouri.
Philip T Levy
Timothy J Sekarski
Aaron Hamvas
Mark R Holland
Gautam K Singh
St. Louis Children's Hospital · USIndiana University School of MedicineNorthwestern University · US

Funding

Data Coordinating Center for the Prematurity and Respiratory Outcomes ProgramU01HL101794 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SCHMIDT, BARBARA · 2010 to 2014
$10.3M
Influence of the Enteric Microbiome on the Genesis of Bronchopulmonary DysplasiaU01HL101465 · NHLBI · WASHINGTON UNIVERSITY · PI FERKOL, THOMAS W, WARNER, BARBARA B · 2010 to 2014
$2.1M
NHLBI NIH HHS U01 HL101465NHLBI NIH HHS U01 HL101794
6 · The paper itself

Abstract

backgroundFrame rate (FR) of image acquisition is an important determinant of the reliability of 2-dimensional speckle tracking echocardiography (2DSTE)-derived myocardial strain. Premature infants have relatively high heart rates (HR). The aim was to analyze the effects of varying FR on the reproducibility of 2DSTE-derived right ventricle (RV) and left ventricle (LV) longitudinal strain (LS) and strain rate (LSR) in premature infants.

methodsRV and LV LS and LSR were measured by 2DSTE in the apical four-chamber view in 20 premature infants (26 ± 1 weeks) with HR 163 ± 13 bpm. For each subject, 4 sets of cine loops were acquired at FR of <90, 90-110, 110-130, and >130 frames/sec. Two observers measured LS and LSR. Inter- and intra-observer reproducibility was assessed using Bland-Altman analysis, coefficient of variation, and linear regression.

resultsIntra-observer reproducibility for RV and LV LS was higher at FR >110 frames/sec, and optimum at FR >130 frames/sec. The highest inter-observer reproducibility for RV and LV LS were at FR >130 and >110 frames/s, respectively. The highest reproducibility for RV and LV systolic and early diastolic LSR was at FR >110 frames/sec. FR/HR ratio >0.7 frames/sec per bpm yielded optimum reproducibility for RV and LV deformation imaging.

conclusionsThe reliability of 2DSTE-derived RV and LV deformation imaging in premature infants is affected by the FR of image acquisition. Reproducibility is most robust when cine loops are obtained with FR/HR ratio between 0.7 and 0.9 frames/sec per bpm, which likely results from optimal myocardial speckle tracking and mechanical event timing.

Indexed as

Infant, PrematureFemaleHeart Defects, CongenitalHumansImage Processing, Computer-AssistedInfant, NewbornMaleObserver VariationProspective StudiesReproducibility of ResultsUltrasonographyframe ratepremature infantsspeckle tracking echocardiographystrainstrain rate

Identifiers

PMID25109389
PMCPMC4324397
OpenAlexW1993255233

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.