Evidence map›Paper›PMID 25109386›Full record

ArticleClinical and translational science2015

The clinical translation gap in child health exercise research: a call for disruptive innovation.

Naveen Ashish, Marcas M Bamman, Frank J Cerny, Dan M Cooper, Pierre D'Hemecourt, Joey C Eisenmann, Dawn Ericson, John Fahey, Bareket Falk, Davera Gabriel and 11 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical and translational science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Comparison of Warm-Up Effects on Maximal Aerobic Exercise Performance in Children.International journal of environmental research and public health · 2022
    Article
  5. Article
  6. Article
  7. A new approach to estimate aerobic fitness using the NHANES dataset.Scandinavian journal of medicine & science in sports · 2019
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Global Data Sharing in Alzheimer Disease Research.Alzheimer disease and associated disorders
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 16 institutions in 2 countries.

Naveen AshishDepartment of Neurology, University of Southern California, California, USA.
Marcas M Bamman
Frank J Cerny
Dan M Cooper
Pierre D'Hemecourt
Joey C Eisenmann
Dawn Ericson
John Fahey
Bareket Falk
Davera Gabriel
Michael G Kahn
Han C G Kemper
Szu-Yun Leu
Robert I Liem
Robert McMurray
Patricia A Nixon
J Tod Olin
Paolo T Pianosi
Mary Purucker
Shlomit Radom-Aizik
Amy Taylor
Boston Children's Hospital · USUniversity of California, Irvine · USBrock University · CAMayo Clinic · USNational Institutes of Health · USNorthwestern University · USSouthern California University for Professional Studies · USUniversity at Buffalo, State University of New York · USUniversity of Alabama at Birmingham · USUniversity of California, Davis · USUniversity of Colorado Boulder · USUniversity of Colorado Denver · USUniversity of North Carolina at Chapel Hill · USWake Forest University · USWestern University of Health Sciences · USYale University · US

Funding

Peripheral Blood Mononuclear Cells, Exercise, and Children: Initial MechanismsP01HD048721 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ADAMS, GREGORY R. · 2006 to 2016
$13.6M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
INSTITUTE FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR031985 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2010 to 2011
$7.2M
Institute for Clinical and Translational ScienceKL2TR000147 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$940k
NCATS NIH HHS KL2 TR000147NCATS NIH HHS UL1 TR000153NCRR NIH HHS 3UL1RR031985NCRR NIH HHS UL1 RR031985NICHD NIH HHS P01 HD048721NICHD NIH HHS P01HD-048721
6 · The paper itself

Abstract

In children, levels of play, physical activity, and fitness are key indicators of health and disease and closely tied to optimal growth and development. Cardiopulmonary exercise testing (CPET) provides clinicians with biomarkers of disease and effectiveness of therapy, and researchers with novel insights into fundamental biological mechanisms reflecting an integrated physiological response that is hidden when the child is at rest. Yet the growth of clinical trials utilizing CPET in pediatrics remains stunted despite the current emphasis on preventative medicine and the growing recognition that therapies used in children should be clinically tested in children. There exists a translational gap between basic discovery and clinical application in this essential component of child health. To address this gap, the NIH provided funding through the Clinical and Translational Science Award (CTSA) program to convene a panel of experts. This report summarizes our major findings and outlines next steps necessary to enhance child health exercise medicine translational research. We present specific plans to bolster data interoperability, improve child health CPET reference values, stimulate formal training in exercise medicine for child health care professionals, and outline innovative approaches through which exercise medicine can become more accessible and advance therapeutics across the broad spectrum of child health.

Indexed as

Child WelfareExerciseOrganizational InnovationResearchTranslational Research, BiomedicalBiomarkersCalibrationChildHealth Planning GuidelinesHumansOxygen ConsumptionResearch PersonnelSemanticsBiomarkerscardiopulmonary exercise testingclinical trialsdata harmonizationexercisepediatrics

Identifiers

PMID25109386
PMCPMC4324404
OpenAlexW1634465826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.