Evidence map›Paper›PMID 25109287›Full record

ArticleActa diabetologica2015

Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents.

Claudia M Toledo-Corral, Tanya L Alderete, Joyce Richey, Paola Sequeira, Michael I Goran, Marc J Weigensberg

Open access · greenAbstract readComparative Study
In one paragraph

Article in Acta diabetologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019
    Article
  7. Article
  8. Article
  9. Adipose Insulin Resistance in Obese Adolescents Across the Spectrum of Glucose Tolerance.The Journal of clinical endocrinology and metabolism · 2016
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Claudia M Toledo-CorralDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Tanya L Alderete
Joyce Richey
Paola Sequeira
Michael I Goran
Marc J Weigensberg
University of Southern California · US

Funding

TYPE 2 DIABETES IN HISPANIC ADOLESCENTSR01DK059211 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC · 2000 to 2013
$9.2M
Using resistance training to reduce metabolic and cardiovascular disease risk inP60MD002254 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC · 2007 to 2011
$8.1M
Southern California Children's Environmental Health Center (SC-CEHC)P01ES022845 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCCONNELL, ROB S · 2013 to 2018
$4.0M
NIDDK NIH HHS R01 DK059211NIDDK NIH HHS R01DK059211NIEHS NIH HHS P01 ES022845NIMHD NIH HHS P60 MD002254NIMHD NIH HHS P60MD002254
6 · The paper itself

Abstract

Type 2 diabetes risk and its relationship to free fatty acid (FFA) exposure and visceral fat by prediabetes status in minority adolescents have yet to be explored. Therefore, the objective of this study was to examine the association of circulating FFA under varying conditions with prediabetes in Latino adolescents and to determine the relative relationships of FFA and visceral adiposity to insulin sensitivity, secretion, and β-cell function. Overweight or obese, but otherwise healthy Latino adolescent males and females (n = 164, 14.2 ± 2.5 years), were recruited for assessment of prediabetes, abdominal fat, and FFA levels taken at a fasting state (FFAF), during an OGTT (FFAOGTT), and overnight (FFANOCTURNAL). Prediabetic adolescents had a higher FFAF than those with normal glucose tolerance when controlling for age, sex, pubertal status, total percent body fat, and visceral fat. FFAOGTT and FFANOCTURNAL did not differ between participants with prediabetes and those with normal glucose tolerance after adjusting for covariates. Visceral fat was independently related to insulin sensitivity and secretion in pubertal adolescents; however, in post-pubertal adolescents, FFAF and visceral fat were both independent and negatively related to β-cell function. These results support a plausible progression of the lipotoxicity theory of diabetes development during the pubertal transition.

Indexed as

AdolescentChildFastingFatty Acids, NonesterifiedFemaleGlucoseGlucose Tolerance TestHispanic or LatinoHumansInsulinIntra-Abdominal FatMaleObesityPrediabetic StateFatty Acids, NonesterifiedGlucoseInsulin

Identifiers

PMID25109287
PMCPMC4324370
OpenAlexW2046262023

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.