Evidence map›Paper›PMID 25108746›Full record

ReviewTrends in microbiology2014

Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus.

Rahul Raman, Kannan Tharakaraman, Zachary Shriver, Akila Jayaraman, V Sasisekharan, Ram Sasisekharan

Open access · bronzeAbstract readReview
In one paragraph

Review in Trends in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Glycans in Virus-Host Interactions: A Structural Perspective.Frontiers in molecular biosciences · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Glycan-protein interactions in viral pathogenesis.Current opinion in structural biology · 2016
    Review
  17. Pathogenesis of Korean SapelovirusA in piglets and chicks.The Journal of general virology · 2016
    Article
  18. Glycomaterials for probing host-pathogen interactions and the immune response.Experimental biology and medicine (Maywood, N.J.) · 2016
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rahul RamanDepartment of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
Kannan TharakaramanDepartment of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
Zachary ShriverDepartment of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
Akila JayaramanDepartment of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
V SasisekharanDepartment of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
Ram SasisekharanDepartment of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA. Electronic address: rams@mit.edu.
Massachusetts Institute of Technology · USSingapore-MIT Alliance for Research and Technology · SG

Funding

Structure-Function Relationship of GlycosaminoglycansR37GM057073 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SASISEKHARAN, RAM · 2010 to 2019
$3.9M
Sequence Analysis of GlycosaminoglycansR01GM057073 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SASISEKHARAN, RAM · 1998 to 2010
$3.1M
NIGMS NIH HHS R01 GM057073NIGMS NIH HHS R37 GM057073NIGMS NIH HHS R37 GM057073-13
6 · The paper itself

Abstract

Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to emerge and result in pandemic outbreaks in humans. Some avian-adapted subtypes have acquired the ability to bind to human glycan receptors and cause severe infections in humans but have yet to adapt to and transmit between humans. The emergence of new avian strains and their ability to infect humans has confounded their distinction from circulating human virus strains through linking receptor specificity to human adaptation. Herein we review the various structural and biochemical analyses of influenza hemagglutinin-glycan receptor interactions. We provide our perspectives on how receptor specificity can be used to monitor evolution of the virus to adapt to human hosts so as to facilitate improved surveillance and pandemic preparedness.

Indexed as

Adaptation, BiologicalEpidemiological MonitoringVirus AttachmentAnimalsHost-Pathogen InteractionsHumansInfluenza A virusInfluenza, HumanOrthomyxoviridae InfectionsPolysaccharidesReceptors, VirusPolysaccharidesReceptors, Virusglycanhemagglutinininfluenzanetworkspecificitytopology

Identifiers

PMID25108746
PMCPMC4252848
OpenAlexW2025057916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.