ArticleSleep & breathing = Schlaf & Atmung2015
Chronic intermittent hypoxia decreases pain sensitivity and increases the expression of HIF1α and opioid receptors in experimental rats.
Article in Sleep & breathing = Schlaf & Atmung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Fibromyalgia in obstructive sleep apnea-hypopnea syndrome: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- The prevalence of fibromyalgia syndrome in individuals with obstructive sleep apnea syndrome and the impact of continuous positive airway pressure treatment on fibromyalgia symptoms.Sleep & breathing = Schlaf & Atmung · 2026Article
- Article
- Mendelian Randomization Analysis Identifies Causal Effects of Multi-Site Chronic Pain on Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
- Intermittent hypoxia induces myofibroblast differentiation and extracellular matrix production of MRC5s via HIF-1α-TGF-β/Smad pathway.Sleep & breathing = Schlaf & Atmung · 2024Article
- Intermittent hypoxia induces Th17/Treg imbalance in a murine model of obstructive sleep apnea.PloS one · 2024Article
- Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord.Journal of bone oncology · 2023Article
- The impact of fibromyalgia syndrome on obstructive sleep apnea syndrome in terms of pain threshold, daytime symptoms, anxiety, depression, disease severity, and sleep quality: a polysomnographic study.Sleep & breathing = Schlaf & Atmung · 2023Article
- Sensitivity to remifentanil and its predictive factor in male patients with moderate to severe obstructive sleep apnea syndrome.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion.Journal of biomedical research · 2022Article
- The Role of Inflammation, Hypoxia, and Opioid Receptor Expression in Pain Modulation in Patients Suffering from Obstructive Sleep Apnea.International journal of molecular sciences · 2022Review
- Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Effects of Obstructive Sleep Apnea and Obesity on Morphine Pharmacokinetics in Children.Anesthesia and analgesia · 2020Article
- Prevalence of obstructive sleep apnea in female patients with fibromyalgia.Saudi medical journal · 2020Article
- Normalizing JMJD6 Expression in Rat Spinal Dorsal Horn Alleviates Hyperalgesia Following Chronic Constriction Injury.Frontiers in neuroscience · 2018Article
- Effect of different levels of intermittent hypoxia on autophagy of hippocampal neurons.Sleep & breathing = Schlaf & Atmung · 2017Article
- The effect of chronic intermittent hypoxia on respiratory sensitivity to morphine in rats.Sleep & breathing = Schlaf & Atmung · 2017Article
- Chronic widespread musculoskeletal pain in patients with obstructive sleep apnea syndrome and the relationship between sleep disorder and pain level, quality of life, and disability.Journal of physical therapy science · 2015Article
- Resolution of fibromyalgia by controlling obstructive sleep apnea with a mandibular advancement device.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present study was designed to determine the effects of chronic intermittent hypoxia (CIH) on pain sensitivity and the changes in the expression of delta-opioid receptor (DOR), mu-opioid receptor (MOR), and hypoxia-inducible factor (HIF)-1α and their relationship with pain sensitivity under hypoxia.
methodsCIH was employed to model the low oxygen condition in obstructive sleep apnea (OSA). Normal oxygen condition was used as control. After 1-, 2-, 3-, and 4-week hypoxia, behavioral tests, including paw-withdrawal latency (PWL) and paw-withdrawal threshold (PWT), were performed. The expressions of DOR, MOR and HIF-1α in cortex were analyzed by real-time PCR and Western blotting.
resultsHIF-1α expression was significantly upregulated after 1-4 weeks of hypoxia at both mRNA and protein levels, compared with the controls (P < 0.05). Both PWL and PWT were significantly enhanced in the rats following 3 and 4 weeks of hypoxia (P < 0.05). DOR and MOR expression was significantly upregulated at both mRNA and protein levels after 3 and 4 weeks of hypoxia (P < 0.05), which corresponded to the behavioral changes.
conclusionsCIH decreases pain sensitivity in rats, possibly through activating HIF-1α and increasing MOR and DOR expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.