Evidence map›Paper›PMID 25108618›Full record

SynthesisJournal of psychiatric research2014

Treating trichotillomania: a meta-analysis of treatment effects and moderators for behavior therapy and serotonin reuptake inhibitors.

Joseph F McGuire, Danielle Ung, Robert R Selles, Omar Rahman, Adam B Lewin, Tanya K Murphy, Eric A Storch

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05207085 (A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Titration Study to Assess the Safety, Tolerability, and Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults), which is not on this map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05207085 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Titration Study to Assess the Safety, Tolerability, and Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults

TypeinterventionalSponsorYale UniversityRan2024 to 2027Enrolled20ConditionsTrichotillomania (Hair-Pulling Disorder)ArmsValbenazine Oral Capsule, Placebo Oral capsule
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 143 citations in OpenAlex.

  1. Pooled it
  2. Pharmacotherapy for trichotillomania.The Cochrane database of systematic reviews · 2021
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  20. Trichotillomania Prevalence in an Arab Middle Eastern Population.Journal of family medicine and primary care · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joseph F McGuireDepartment of Psychology, University of South Florida, United States; Department of Pediatrics, University of South Florida, United States. Electronic address: jfmcguire@mail.usf.edu.
Danielle UngDepartment of Psychology, University of South Florida, United States; Department of Pediatrics, University of South Florida, United States.
Robert R SellesDepartment of Psychology, University of South Florida, United States; Department of Pediatrics, University of South Florida, United States.
Omar RahmanDepartment of Pediatrics, University of South Florida, United States.
Adam B LewinDepartment of Psychology, University of South Florida, United States; Department of Pediatrics, University of South Florida, United States; Department of Psychiatry and Behavioral Neurosciences, University of South Florida, United States.
Tanya K MurphyDepartment of Pediatrics, University of South Florida, United States; Department of Psychiatry and Behavioral Neurosciences, University of South Florida, United States.
Eric A StorchDepartment of Psychology, University of South Florida, United States; Department of Pediatrics, University of South Florida, United States; Department of Psychiatry and Behavioral Neurosciences, University of South Florida, United States; Rogers Behavioral Health - Tampa Bay, United States; All Children's Hospital - Johns Hopkins Medicine, United States.
University of South Florida · USJohns Hopkins All Children's Hospital · US

Funding

1/2-D-Cycloserine Augmentation of CBT for Pediatric OCDR01MH093381 · NIMH · UNIVERSITY OF SOUTH FLORIDA · PI STORCH, ERIC A. · 2011 to 2014
$1.2M
NIMH NIH HHS MH093381NIMH NIH HHS R01 MH093381NIMH NIH HHS R01MH093381
6 · The paper itself

Abstract

Few randomized controlled trials (RCTs) exist examining the efficacy of behavior therapy (BT) or serotonin reuptake inhibitors (SRIs) for the treatment of trichotillomania (TTM), with no examination of treatment moderators. The present meta-analysis synthesized the treatment effect sizes (ES) of BT and SRI relative to comparison conditions, and examined moderators of treatment. A comprehensive literature search identified 11 RCTs that met inclusion criteria. Clinical characteristics (e.g., age, comorbidity, therapeutic contact hours), outcome measures, treatment subtypes (e.g., SRI subtype, BT subtype), and ES data were extracted. The standardized mean difference of change in hair pulling severity was the outcome measure. A random effects meta-analysis found a large pooled ES for BT (ES = 1.41, p < 0.001). BT trials with greater therapeutic contact hours exhibited larger ES (p = 0.009). Additionally, BT trials that used mood enhanced therapeutic techniques exhibited greater ES relative to trials including only traditional BT components (p = 0.004). For SRI trials, a random effects meta-analysis identified a moderate pooled ES (ES = 0.41, p = 0.02). Although clomipramine exhibited larger ES relative to selective serotonin reuptake inhibitors, the difference was not statistically significant. Publication bias was not identified for either treatment. BT yields large treatment effects for TTM, with further examination needed to disentangle confounded treatment moderators. SRI trials exhibited a moderate pooled ES, with no treatment moderators identified. Sensitivity analyses highlighted the need for further RCTs of SRIs, especially among youth with TTM.

Indexed as

AdolescentAdultAnalysis of VarianceBehavior TherapyClomipramineFemaleHumansMaleRandomized Controlled Trials as TopicReproducibility of ResultsSelective Serotonin Reuptake InhibitorsTreatment OutcomeTrichotillomaniaYoung AdultClomipramineSelective Serotonin Reuptake InhibitorsBehavior therapyClomipramineHabit reversal trainingHair pulling disorderObsessive–compulsive spectrum disordersSelective serotonin reuptake inhibitors

Identifiers

PMID25108618
PMCPMC4163503
OpenAlexW2160932918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.