ReviewPsychoneuroendocrinology2014
A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders.
Review in Psychoneuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Maternal atopic conditions and autism spectrum disorder: a systematic review.European child & adolescent psychiatry · 2024Pooled it
- Hyperandrogenism? Increased 17, 20-Lyase Activity? A Metanalysis and Systematic Review of Altered Androgens in Boys and Girls with Autism.International journal of molecular sciences · 2021Pooled it
- Cortisol awakening response in children and adolescents with autism spectrum disorder: a systematic review and meta-analysis.Evidence-based mental health · 2019Pooled it
- Therapeutic Riding or Mindfulness: Comparative Effectiveness of Two Recreational Therapy Interventions for Adolescents with Autism.Journal of autism and developmental disorders · 2022Trial
- Oxytocin receptor neurons in the paraventricular thalamus as a nexus for social behaviour and fear.Brain : a journal of neurology · 2026Article
- Affect Expression During Social and Non-Social Contexts in Autistic Young Adults.Journal of autism and developmental disorders · 2026Article
- Concurrent Assessment of Neurotrophic Factors and HPA-Axis Hormones in Early Childhood Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- The cortisol axis and psychiatric disorders: an updated review.Pharmacological reports : PR · 2025Review
- The Association Between Adverse Childhood Experiences and Sleep in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2025Article
- The Impact of the COVID-19 Pandemic on Young Adults with Autism Spectrum Disorder: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Cortisol as a Biomarker for Stress During the Assessment and Treatment of Destructive Behavior.Behavioral sciences (Basel, Switzerland) · 2025Article
- Unveiling complex patterns: An information-theoretic approach to high-order behaviors in microarray data.PloS one · 2025Article
- Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing.Frontiers in molecular biosciences · 2025Article
- Oral Supplementation of L-Carnosine Attenuates Acute-Stress-Induced Corticosterone Release and Mitigates Anxiety in CD157 Knockout Mice.Nutrients · 2024Article
- Cognitive emotion regulation difficulties increase affective reactivity to daily-life stress in autistic adolescents and young adults.Autism : the international journal of research and practice · 2024Article
- Article
- Social Context in Stress and Autism: Comparing Physiological Profiles Across Two Social Paradigms in Youth with and without Autism Spectrum Disorder.Research in autism spectrum disorders · 2024Article
- Relationship between serum cortisol levels, stereotypies, and the presence of autism spectrum disorder in patients with severe intellectual disability.Scientific reports · 2024Article
- Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance.Nature reviews. Gastroenterology & hepatology · 2024Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Examination of the hypothalamic-pituitary-adrenal (HPA) axis via cortisol among individuals with autism spectrum disorder (ASD) has been a growing area of research interest. The following review includes investigations of cortisol conducted with cohorts of individuals with ASD across the lifespan over the past four decades. In general, studies find dysregulation when examining the diurnal rhythm as a whole in lower functioning children with ASD; however, limited evidence exists for alterations in higher functioning individuals and in specific aspects of the diurnal cycle (cortisol awakening response, daily decline, variability) relative to typically developing individuals. Studies examining the responsiveness of cortisol in ASD suggest an overall sluggishness of the HPA axis in responding to physiological or physical manipulation. Hypo-responsiveness was observed in stressors that involve social evaluative threat, however, hyper-responsiveness of the HPA axis was observed in situations involving unpleasant stimuli or relatively benign social situations. A number of important considerations when conducting studies of cortisol in ASD cohorts are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.