Evidence map›Paper›PMID 25107980›Full record

ArticleApplied and environmental microbiology2014

Molecular basis of the behavior of hepatitis a virus exposed to high hydrostatic pressure.

Lucía D'Andrea, Francisco J Pérez-Rodríguez, M Isabel Costafreda, Nerea Beguiristain, Cristina Fuentes, Teresa Aymerich, Susana Guix, Albert Bosch, Rosa M Pintó

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lucía D'AndreaEnteric Virus Laboratory, Department of Microbiology, School of Biology, University of Barcelona, Barcelona, Spain Enteric Virus Laboratory, Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Santa Coloma de Gramenet, Spain.
Francisco J Pérez-RodríguezEnteric Virus Laboratory, Department of Microbiology, School of Biology, University of Barcelona, Barcelona, Spain Enteric Virus Laboratory, Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Santa Coloma de Gramenet, Spain.
M Isabel CostafredaEnteric Virus Laboratory, Department of Microbiology, School of Biology, University of Barcelona, Barcelona, Spain Enteric Virus Laboratory, Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Santa Coloma de Gramenet, Spain.
Nerea BeguiristainEnteric Virus Laboratory, Department of Microbiology, School of Biology, University of Barcelona, Barcelona, Spain Enteric Virus Laboratory, Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Santa Coloma de Gramenet, Spain.
Cristina FuentesEnteric Virus Laboratory, Department of Microbiology, School of Biology, University of Barcelona, Barcelona, Spain Enteric Virus Laboratory, Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Santa Coloma de Gramenet, Spain.
Teresa AymerichCENTA, IRTA, Monells, Spain.
Susana GuixEnteric Virus Laboratory, Department of Microbiology, School of Biology, University of Barcelona, Barcelona, Spain Enteric Virus Laboratory, Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Santa Coloma de Gramenet, Spain.
Albert BoschEnteric Virus Laboratory, Department of Microbiology, School of Biology, University of Barcelona, Barcelona, Spain Enteric Virus Laboratory, Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Santa Coloma de Gramenet, Spain.
Rosa M PintóEnteric Virus Laboratory, Department of Microbiology, School of Biology, University of Barcelona, Barcelona, Spain Enteric Virus Laboratory, Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Santa Coloma de Gramenet, Spain rpinto@ub.edu.
Universitat de Barcelona · ESFundación Pública Andaluza Centro de las Nuevas Tecnologías del Agua · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food-borne hepatitis A outbreaks may be prevented by subjecting foods at risk of virus contamination to moderate treatments of high hydrostatic pressure (HHP). A pretreatment promoting hepatitis A virus (HAV) capsid-folding changes enhances the virucidal effect of HHP, indicating that its efficacy depends on capsid conformation. HAV populations enriched in immature capsids (125S provirions) are more resistant to HHP, suggesting that mature capsids (150S virions) are more susceptible to this treatment. In addition, the monoclonal antibody (MAb) K24F2 epitope contained in the immunodominant site is a key factor for the resistance to HHP. Changes in capsid folding inducing a loss of recognition by MAb K24F2 render more susceptible conformations independently of the origin of such changes. Accordingly, codon usage-associated folding changes and changes stimulated by pH-dependent breathings, provided they confer a loss of recognition by MAb K24F2, induce a higher susceptibility to HHP. In conclusion, the resistance of HAV to HHP treatments may be explained by a low proportion of 150S particles combined with a good accessibility of the epitope contained in the immunodominant site close to the 5-fold axis.

Indexed as

Virus InactivationCapsidEpitopesHepatitis A virusHydrostatic PressureOxidoreductases1-ene-dehydrogenaseEpitopesOxidoreductases

Identifiers

PMID25107980
PMCPMC4178634
OpenAlexW2011539282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.