ArticleApplied and environmental microbiology2014
Transcriptomic responses of Phanerochaete chrysosporium to oak acetonic extracts: focus on a new glutathione transferase.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review.iScience · 2022Review
- Omics analyses and biochemical study of Phlebiopsis gigantea elucidate its degradation strategy of wood extractives.Scientific reports · 2021Article
- Conserved white-rot enzymatic mechanism for wood decay in the Basidiomycota genus Pycnoporus.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- Seeking the Roles for Fungal Small-Secreted Proteins in Affecting Saprophytic Lifestyles.Frontiers in microbiology · 2020Review
- Genome description of Phlebia radiata 79 with comparative genomics analysis on lignocellulose decomposition machinery of phlebioid fungi.BMC genomics · 2019Article
- Interdependence of Primary Metabolism and Xenobiotic Mitigation Characterizes the Proteome of Bjerkandera adusta during Wood Decomposition.Applied and environmental microbiology · 2018Article
- A role for small secreted proteins (SSPs) in a saprophytic fungal lifestyle: Ligninolytic enzyme regulation in Pleurotus ostreatus.Scientific reports · 2017Article
- Gene expression metadata analysis reveals molecular mechanisms employed by Phanerochaete chrysosporium during lignin degradation and detoxification of plant extractives.Current genetics · 2017Article
- Secretion of small proteins is species-specific within Aspergillus sp.Microbial biotechnology · 2017Article
- Metadata Analysis ofInternational journal of biological sciences · 2017Article
- Localizing gene regulation reveals a staggered wood decay mechanism for the brown rot fungus Postia placenta.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Regulation of Gene Expression during the Onset of Ligninolytic Oxidation by Phanerochaete chrysosporium on Spruce Wood.Applied and environmental microbiology · 2015Article
- Characterization of glutathione transferases involved in the pathogenicity of Alternaria brassicicola.BMC microbiology · 2015Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first steps of wood degradation by fungi lead to the release of toxic compounds known as extractives. To better understand how lignolytic fungi cope with the toxicity of these molecules, a transcriptomic analysis of Phanerochaete chrysosporium genes was performed in the presence of oak acetonic extracts. It reveals that in complement to the extracellular machinery of degradation, intracellular antioxidant and detoxification systems contribute to the lignolytic capabilities of fungi, presumably by preventing cellular damages and maintaining fungal health. Focusing on these systems, a glutathione transferase (P. chrysosporium GTT2.1 [PcGTT2.1]) has been selected for functional characterization. This enzyme, not characterized so far in basidiomycetes, has been classified first as a GTT2 compared to the Saccharomyces cerevisiae isoform. However, a deeper analysis shows that the GTT2.1 isoform has evolved functionally to reduce lipid peroxidation by recognizing high-molecular-weight peroxides as substrates. Moreover, the GTT2.1 gene has been lost in some non-wood-decay fungi. This example suggests that the intracellular detoxification system evolved concomitantly with the extracellular ligninolytic machinery in relation to the capacity of fungi to degrade wood.
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