ReviewMolecular neurobiology1989
G protein regulation of phospholipase A2.
Review in Molecular neurobiology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: aMolecular psychiatry · 2025Pooled it
- Natural variation in Glume Coverage 1 causes naked grains in sorghum.Nature communications · 2022Article
- Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism.The Biochemical journal · 1997Article
- Interactions of bradykinin, calcium, G-protein and protein kinase in the activation of phospholipase A2 in bovine pulmonary artery endothelial cells.Agents and actions · 1993Article
- Lipid metabolism of myocardial endothelial cells.Molecular and cellular biochemistry · 1992Review
- Assay of phospholipases A(2) and their inhibitors by kinetic analysis in the scooting mode.Mediators of inflammation · 1992Article
- Bidirectional control of phospholipase A2 activity by Ca2+/calmodulin-dependent protein kinase II, cAMP-dependent protein kinase, and casein kinase II.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- GTP-binding proteins and potassium channels involved in synaptic plasticity and learning.Molecular neurobiology · 1991Review
- Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many neurotransmitters and hormones activate receptors that are known to be coupled to their effectors by GTP-binding regulatory proteins, G proteins. Activation of many of these same receptors elicits arachidonate release and metabolism. During the past few years, novel experimental techniques have revealed that in many cells arachidonate release is independent of generation of other second messengers, including inositol phosphates, diacylglycerols, and elevation in free intracellular calcium. Much evidence has accumulated to implicate phospholipase A2 as the enzyme catalyzing arachidonate release, and suggesting that this effector enzyme, too, is activated by G proteins. In neural tissues as well as epithelium, endothelium, contractile and connective tissues, and blood cells, G proteins coupled to receptors for a variety of peptide and nonpeptide neurotransmitters and hormones have been shown to directly activate phospholipase A2. In retinal rod outer segments, transducin is the coupling G protein, but the G proteins coupling receptor activation to phospholipase A2 in other cell types is less clear. Some are pertussis toxin-sensitive, whereas others are not, and evidence exists that the ras gene product G protein may also be coupled to and regulate phospholipase A2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.