ArticlePlant molecular biology2014
Functions of EDS1-like and PAD4 genes in grapevine defenses against powdery mildew.
Article in Plant molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Identification of Genes Involved in Resistance to Flavescence Dorée Disease of Grapevine: A Model Study Using Arabidopsis thaliana.Molecular plant pathology · 2026Article
- Silica nanoparticles enhance resistance of Vitis vinifera to downy mildew.BMC plant biology · 2026Article
- Genome-wide identification and functional characterisation of the EDS1 gene family reveals evolutionary conservation and stress-responsive regulatory roles in barley.Scientific reports · 2026Article
- Phase-Dependent Transcriptional Reprogramming ofInternational journal of molecular sciences · 2025Article
- Genome-wide identification of GhEDS1 gene family members in cotton and expression analysis in response to biotic and abiotic stresses.BMC plant biology · 2025Article
- Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus).BMC plant biology · 2025Article
- Genome-wide comprehensive analysis the molecular phylogenetic evolution, functional divergence and tissue-specific expression ofFrontiers in plant science · 2025Article
- Genome-wide identification ofFrontiers in plant science · 2025Article
- A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4.Protein science : a publication of the Protein Society · 2023Article
- Identifications of QTLs and Candidate Genes Associated withInternational journal of molecular sciences · 2023Article
- Kaolin Particle Film Protects Grapevine cv. Cabernet Sauvignon Against Downy Mildew by Forming Particle Film at the Leaf Surface, Directly Acting on Sporangia and Inducing the Defense of the Plant.Frontiers in plant science · 2021Article
- Article
- A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors.The Plant cell · 2019Article
- Biotechnological Potential of LSD1, EDS1, and PAD4 in the Improvement of Crops and Industrial Plants.Plants (Basel, Switzerland) · 2019Review
- An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis.Nature communications · 2019Article
- Genome-wide analysis of cotton GH3 subfamily II reveals functional divergence in fiber development, hormone response and plant architecture.BMC plant biology · 2018Article
- Lipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa.Nature communications · 2018Article
- Non-host Plant Resistance againstFrontiers in plant science · 2017Article
- Ectopic Expression of the Wild Grape WRKY Transcription Factor VqWRKY52 inFrontiers in plant science · 2017Article
- Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine.Horticulture research · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular interactions between grapevine and the obligate biotrophic fungus Erysiphe necator are not understood in depth. One reason for this is the recalcitrance of grapevine to genetic modifications. Using defense-related Arabidopsis mutants that are susceptible to pathogens, we were able to analyze key components in grapevine defense responses. We have examined the functions of defense genes associated with the salicylic acid (SA) pathway, including ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), EDS1-LIKE 2 (EDL2), EDL5 and PHYTOALEXIN DEFICIENT 4 (PAD4) of two grapevine species, Vitis vinifera cv. Cabernet Sauvignon, which is susceptible to E. necator, and V. aestivalis cv. Norton, which is resistant. Both VaEDS1 and VvEDS1 were previously found to functionally complement the Arabidopsis eds1-1 mutant. Here we show that the promoters of both VaEDS1 and VvEDS1 were induced by SA, indicating that the heightened defense of Norton is related to its high SA level. Other than Va/VvEDS1, only VaEDL2 complemented Arabidopsis eds1-1, whereas Va/VvPAD4 did not complement Arabidopsis pad4-1. Bimolecular fluorescence complementation results indicated that Vitis EDS1 and EDL2 proteins interact with Vitis PAD4 and AtPAD4, suggesting that Vitis EDS1/EDL2 forms a complex with PAD4 to confer resistance, as is known from Arabidopsis. However, Vitis EDL5 and PAD4 did not interact with Arabidopsis EDS1 or PAD4, correlating with their inability to function in Arabidopsis. Together, our study suggests a more complicated EDS1/PAD4 module in grapevine and provides insight into molecular mechanisms that determine disease resistance levels in Vitis species native to the North American continent.
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