ArticleNeuropharmacology2015
Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.
Article in Neuropharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice.The Journal of biological chemistry · 2016Guideline
- Increased excitability of layer 5 neocortical pyramidal neurons and its contribution to seizure activity in Gabrg2 gene-deficient mice.iScience · 2026Article
- Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure.Molecular psychiatry · 2025Article
- Study on the Mechanism ofNutrients · 2024Article
- Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure.bioRxiv : the preprint server for biology · 2024Article
- Increased number of excitatory synapsis and decreased number of inhibitory synapsis in the prefrontal cortex in autism.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- GABATrends in pharmacological sciences · 2023Review
- Article
- Extracellular molecular signals shaping dendrite architecture during brain development.Frontiers in cell and developmental biology · 2023Review
- Therapeutic non-invasive brain treatments in Alzheimer's disease: recent advances and challenges.Inflammation and regeneration · 2022Review
- Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice.Cell death & disease · 2021Article
- Article
- Regulatory mechanisms of major depressive disorder risk variants.Molecular psychiatry · 2020Article
- Mild chronic perturbation of inhibition severely alters hippocampal function.Scientific reports · 2019Article
- Molecular basis for and chemogenetic modulation of comorbidities in GABRG2-deficient epilepsies.Epilepsia · 2019Article
- Diazepam Accelerates GABAFrontiers in cellular neuroscience · 2019Article
- Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience.F1000Research · 2019Review
- Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior.Frontiers in molecular neuroscience · 2019Article
- Mechanism of Repetitive Transcranial Magnetic Stimulation for Depression.Shanghai archives of psychiatry · 2018Review
- γ2 GABAFrontiers in cellular neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Mice that were rendered heterozygous for the γ2 subunit of GABAA receptors (γ2(+/-) mice) have been characterized extensively as a model for major depressive disorder. The phenotype of these mice includes behavior indicative of heightened anxiety, despair, and anhedonia, as well as defects in hippocampus-dependent pattern separation, HPA axis hyperactivity and increased responsiveness to antidepressant drugs. The γ2(+/-) model thereby provides strong support for the GABAergic deficit hypothesis of major depressive disorder. Here we show that γ2(+/-) mice additionally exhibit specific defects in late stage survival of adult-born hippocampal granule cells, including reduced complexity of dendritic arbors and impaired maturation of synaptic spines. Moreover, cortical γ2(+/-) neurons cultured in vitro show marked deficits in GABAergic innervation selectively when grown under competitive conditions that may mimic the environment of adult-born hippocampal granule cells. Finally, brain extracts of γ2(+/-) mice show a numerical but insignificant trend (p = 0.06) for transiently reduced expression of brain derived neurotrophic factor (BDNF) at three weeks of age, which might contribute to the previously reported developmental origin of the behavioral phenotype of γ2(+/-) mice. The data indicate increasing congruence of the GABAergic, glutamatergic, stress-based and neurotrophic deficit hypotheses of major depressive disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.