ArticleProstaglandins, leukotrienes, and essential fatty acids2014
Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest.
Article in Prostaglandins, leukotrienes, and essential fatty acids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Lifestyle Factors Associated with Circulating Very Long-Chain Saturated Fatty Acids in Humans: A Systematic Review of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Pooled it
- Genetic loci associated with circulating levels of very long-chain saturated fatty acids.Journal of lipid research · 2015Pooled it
- Free Fatty Acids Correlate with the Interleukin-1 β and Interleukin-1 Receptor Antagonist in the Early Subacute Phase of Stroke.Biomolecules · 2025Article
- Wildfire smoke induces GM3 ganglioside lipid accumulation and transcriptomic shifts in mouse lung tissue: A smoke signal story.The Science of the total environment · 2025Article
- The Effects of Lighted Incubation on Traits and Composition of Broiler Breast Meat.Veterinary medicine and science · 2025Article
- The Effect of Dietary Propylene Glycol on the Fatty Acid Composition of Three Fat Depots in Male Akkaraman Lambs.Veterinary medicine and science · 2025Article
- Serum lipidomic analysis identifies potential therapeutic targets for neurodegeneration.Frontiers in human neuroscience · 2025Article
- Article
- Association of Circulating Very Long-Chain Saturated Fatty Acids With Cardiovascular Mortality in NHANES 2003-2004, 2011-2012.The Journal of clinical endocrinology and metabolism · 2024Article
- Plasma Ceramides and Sphingomyelins and Sudden Cardiac Death in the Cardiovascular Health Study.JAMA network open · 2023Article
- Effect of Crushing Peanuts on Fatty Acid and Phenolic Bioaccessibility: A Long-Term Study.Antioxidants (Basel, Switzerland) · 2022Article
- Circulating saturated fatty acids and risk of gestational diabetes mellitus: A cross-sectional study and meta-analysis.Frontiers in nutrition · 2022Article
- Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort.The American journal of clinical nutrition · 2021Article
- Assessment of Plasma Phospholipid Very-Long-Chain Saturated Fatty Acid Levels and Healthy Aging.JAMA network open · 2021Article
- Association of Dietary Fatty Acid Consumption Patterns with Risk of Hyper-LDL Cholesterolemiain Korean Adults.Nutrients · 2020Article
- Circulating Very-Long-Chain SFA Concentrations Are Inversely Associated with Incident Type 2 Diabetes in US Men and Women.The Journal of nutrition · 2020Article
- MicroRNA-21 abrogates palmitate-induced cardiomyocyte apoptosis through caspase-3/NF-κB signal pathways.Anatolian journal of cardiology · 2018Article
- A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma.International journal of cancer · 2018Article
- Neighborhood food environment, dietary fatty acid biomarkers, and cardiac arrest risk.Health & place · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Prior studies suggest that circulating n-3 and trans-fatty acids influence the risk of sudden cardiac arrest (SCA). Yet, while other fatty acids also differ in their membrane properties and biological activities which may influence SCA, little is known about the associations of other circulating fatty acids with SCA. The aim of this study was to investigate the associations of 17 erythrocyte membrane fatty acids with SCA risk. We used data from a population-based case-control study of SCA in the greater Seattle, Washington, area. Cases, aged 25-74 years, were out-of-hospital SCA patients, attended by paramedics (n=265). Controls, matched to cases by age, sex and calendar year, were randomly identified from the community (n=415). All participants were free of prior clinically-diagnosed heart disease. Blood was obtained at the time of cardiac arrest by attending paramedics (cases) or at the time of an interview (controls). Higher levels of erythrocyte very long-chain saturated fatty acids (VLSFA) were associated with lower risk of SCA. After adjustment for risk factors and levels of n-3 and trans-fatty acids, higher levels of 20:0 corresponding to 1 SD were associated with 30% lower SCA risk (13-43%, p=0.001). Higher levels of 22:0 and 24:0 were associated with similar lower SCA risk (ORs for 1 SD-difference: 0.71 [95% CI: 0.57-0.88, p=0.002] for 22:0; and 0.79 [95% CI: 0.63-0.98, p=0.04] for 24:0). These novel findings support the need for investigation of biologic effects of circulating VLSFA and their determinants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.