Evidence map›Paper›PMID 25107531›Full record

ArticleArchives of biochemistry and biophysics2014

MAGE proteins regulate KRAB zinc finger transcription factors and KAP1 E3 ligase activity.

Tony Z Xiao, Yewseok Suh, B Jack Longley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. TRIM28 in cancer and cancer therapy.Frontiers in genetics · 2024
    Review
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. The MAGE protein family and cancer.Current opinion in cell biology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tony Z XiaoDepartment of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA. Electronic address: Txiao@dermatology.wisc.edu.
Yewseok SuhDepartment of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
B Jack LongleyDepartment of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA; Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA. Electronic address: bjlongley@dermatology.wisc.edu.
University of Wisconsin–Madison · US

Funding

The Cutaneous Biology of MAGE Transcription FactorsR21AR062773 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI LONGLEY, B JACK · 2012 to 2013
$364k
NIAMS NIH HHS R21 AR062773
6 · The paper itself

Abstract

Expression of Melanoma AntiGen Encoding (MAGE) genes, particularly MAGE-A3, has been correlated with aggressive clinical course, the acquisition of resistance to chemotherapy and poor clinical outcomes of melanoma and other malignancies. MAGE proteins bind to KAP1, a gene repressor and ubiquitin E3 ligase which also binds KRAB domain containing zinc finger transcription factors (KZNFs), and MAGE expression may affect KZNF mediated gene regulation. To investigate mechanisms for these effects, we tested the hypothesis that differences in KRAB domain composition affect KZNF poly-ubiquitination and determine whether MAGE expression increases, decreases, or has no effect on KZNFs mediated gene repression. Using an integrated reporter gene responsive to repression by KRAB domain fusion proteins, we found that MAGE-A3 relieved KZNF mediated repression and induced KZNF poly-ubiquitination and degradation in association with expression of the A+B box KRAB domain. In contrast, MAGE-A3 enhanced KAP1 mediated repression of KZNFs expressing A or A+b box KRAB domains but caused no increase in poly-ubiquitination or degradation. MAGE-A3 has no significant impact on KZNFs with KRAB domains containing the Scan box motif. These data support our hypothesis by showing that the effects of MAGE-A3 on gene repression depend on the type of KZNF KRAB domain involved.

Indexed as

AnimalsAntigens, NeoplasmCHO CellsCricetulusGene Expression Regulation, NeoplasticHEK293 CellsHumansMelanomaModels, MolecularNeoplasm ProteinsProtein Interaction Domains and MotifsRecombinant Fusion ProteinsRepressor ProteinsTripartite Motif-Containing Protein 28UbiquitinationUbiquitin-Protein LigasesAntigens, NeoplasmMAGEA3 protein, humanMAGEC2 protein, humanNeoplasm ProteinsRecombinant Fusion ProteinsRepressor ProteinsTRIM28 protein, humanTripartite Motif-Containing Protein 28Ubiquitin-Protein LigasesZNF350 protein, humanKRABMAGEMelanomaZNF

Identifiers

PMID25107531
PMCPMC4221552
OpenAlexW1967828550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.